Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors

Heat shock protein 90 (Hsp90) chaperone proteins stabilize well over 200 different known
client proteins helping them to fold correctly as they take up their rightful positions in
the cell. Inhibitors of the chaperone protein Hsp90 are of current interest because of the
central role of Hsp90 in the maturation and maintenance of numerous proteins that are
critical for tumor cell viability and growth. SNX-5422 is a pro-drug of SNX-2112, a potent,
highly selective, small-molecule inhibitor of the molecular chaperone heat shock protein 90
(Hsp90). The study will determine the maximum tolerated dose (MTD) of SNX-5422 when combined
with carboplatin plus paclitaxel in selected solid tumors and assess the safety and efficacy
of SNX-5422 alone dosed at the MTD as maintenance therapy in selected solid tumors treatment.

Inclusion Criteria:

- Males or non-pregnant, non-breastfeeding females 18 years-of-age or older.

- Pathologic evidence of Small Cell Lung Cancer, or Non-Small Cell Lung Cancer.

- No more than one prior line of antitumor therapy for metastatic disease, excluding
prior treatment with tyrosine kinase inhibitors. An interval of at least 1 week is
required for washout of the tyrosine kinase inhibitor.

- Measurable disease using RECIST criteria (version 1.1).

- Life expectancy of at least 3 months.

- Karnofsky performance score ≥70.

- Adequate baseline laboratory assessments, including:

- Absolute neutrophil count (ANC) ≥1.5 x 109/L.

- WBC >3000/microliter.

- Platelet count of ≥100 x 109/L.

- Total bilirubin level ≤1.5 times institutional upper limit of normal (ULN),
alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≤2.0 x ULN
except in subjects with known hepatic metastasis, where AST or ALT can be ≤5.0 x
ULN.

- Hemoglobin ≥9 mg/dL.

- Estimated creatinine clearance of ≥40 mL/min

- Recovered from toxicities of previous anticancer therapy to CTCAE Grade ≤ 1 with the
exception of alopecia.

- Signed informed consent form (ICF)

- Subjects with reproductive capability must agree to practice adequate contraception
methods.

- Adequate venous access

Exclusion Criteria:

- CNS metastases that are symptomatic and /or requiring steroids.

- Prior treatment with any Hsp90 inhibitor.

- Major surgery or significant traumatic injury within 4 weeks of starting study
treatment.

- The need for treatment with medications with clinically relevant metabolism by the
cytochrome P450 (CYP) 3A4 isoenzyme within 3 hours before or after administration of
SNX-5422

- Screening ECG QTc interval ≥ 470 msec for females, ≥ 450 msec for males.

- At increased risk for developing prolonged QT interval, including hypokalemia or
hypomagnesemia, unless corrected to within normal limits prior to first dose of
SNX-5422; congenital long QT syndrome or a history of torsade de pointes; currently
receiving anti-arrhythmics or other medications that may be associated with QT
prolongation

- Patients with chronic diarrhea or with grade 2 or greater diarrhea despite maximal
medical management.

- Gastrointestinal diseases or conditions that could affect drug absorption, including
gastric bypass.

- Gastrointestinal diseases that could alter the assessment of safety, including
irritable bowel syndrome, ulcerative colitis, Crohn's disease, or hemorrhagic
coloproctitis.

- History of documented adrenal dysfunction not due to malignancy.

- Known seropositive for human immunodeficiency virus (HIV) or hepatitis C virus (HCV).

- History of chronic liver disease.

- Active hepatitis A or B.

- Current alcohol dependence or drug abuse.

- Treatment with other anticancer drugs within 28 days or 5 half-lives of anticancer
therapy (whichever is shorter), and treatment with any other investigational agent is
prohibited from 30 days prior to the first dose of SNX-5422 and throughout the study.

- Radiation treatment within 2 weeks.

- Glaucoma, retinitis pigmentosa, macular degeneration, or any retinal changes detected
by ophthalmological examination.

- Other serious concurrent illness or medical condition.

- Psychological, social, familial, or geographical reasons that would hinder or prevent
compliance with the requirements of the protocol or compromise the informed consent
process.