Study of Intravenous Ceftolozane/Tazobactam Compared to Piperacillin/Tazobactam in Ventilator-Associated Pneumonia



Status:Terminated
Conditions:Pneumonia
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - Any
Updated:11/18/2018
Start Date:June 14, 2013
End Date:December 8, 2013

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A Multicenter, Open-Label, Randomized Study to Compare the Safety and Efficacy of Intravenous Ceftolozane/Tazobactam With That of Piperacillin/Tazobactam in Ventilator Associated Pneumonia

This is a Phase 3, multicenter, prospective, randomized, open-label, study to compare the
safety and efficacy of intravenous (IV) ceftolozane/tazobactam with that of IV
piperacillin/tazobactam in the treatment of ventilator-associated pneumonia (VAP) in adult
participants .


Key Inclusion Criteria:

- Participant has received mechanical ventilation for > 48 hours

- Acute Physiology and Chronic Health Evaluation (APACHE) II score of 11-35

- Presence of a new or progressive infiltrate on chest x-ray

- Presence of clinical criteria consistent with VAP

Key Exclusion Criteria:

- History of moderate or severe hypersensitivity reactions to beta-lactam antibiotics

- Known end stage renal disease or requirement for dialysis
We found this trial at
12
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