Studying Protein Expression in Tissue Samples From Younger Patients With Rhabdomyosarcoma



Status:Recruiting
Conditions:Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any - 21
Updated:4/21/2016
Start Date:June 2012

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Trial Summary
Trial Overview
Inclusion Criteria

Tissue Microarray Studies of the 12q13-q14 Amplicon in Alveolar Rhabdomyosarcoma

This research trial studies protein expression in tissue samples from younger patients with
rhabdomyosarcoma. Studying samples of tissue from patients with cancer in the laboratory may
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer. It may also help doctors find better ways to treat cancer.

PRIMARY OBJECTIVES:

I. To investigate (in two stages) which proteins are overexpressed in association with
12q13-q14 amplification by applying fluorescence in situ hybridization (FISH) and
immunohistochemical (IHC) assays to a panel of alveolar rhabdomyosarcomas (ARMS) cases
organized into tissue microarrays.

OUTLINE:

Formalin-fixed paraffin-embedded tissue samples are analyzed for 12q13-q14 frequency and
protein overexpression by FISH and IHC.

Inclusion Criteria:

- Slides of the 2006 alveolar rhabdomyosarcoma (ARMS) TMA and the 2009 ARMS/anaplastic
embryonal rhabdomyosarcoma (ERMS) TMA

- PAX3-FOXO1-positive tumors

- PAX7-FOXO1-positive tumors

- Fusion-negative tumors
We found this trial at
1
site
Children's Oncology Group
Monrovia, California 91016
Principal Investigator: Frederic G. Barr, MD
Phone: 301-594-3780
?
mi
from
Monrovia, CA
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