Plasma Triglyceride Extraction by The Muscle
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 8/24/2018 |
| Start Date: | April 2013 |
| End Date: | September 19, 2019 |
Regulation of the Plasma Triglyceride Extraction in Muscle in Insulin Resistance
Increased accumulation of fat into the muscles is associated with what is called
insulin-resistant state, which is a pre-diabetic state. The purpose of this research is to
find out how fat circulating in the blood following fat consumption is taken up by the
muscles in healthy people as well as people that are insulin-resistant. The investigators are
specifically interested in how a hormone called insulin is involved in this process. Findings
from this research will contribute to our understanding of why insulin-resistant people have
increased accumulation of fat in their muscles, and ultimately help to design appropriate
interventions to prevent type 2 Diabetes.
insulin-resistant state, which is a pre-diabetic state. The purpose of this research is to
find out how fat circulating in the blood following fat consumption is taken up by the
muscles in healthy people as well as people that are insulin-resistant. The investigators are
specifically interested in how a hormone called insulin is involved in this process. Findings
from this research will contribute to our understanding of why insulin-resistant people have
increased accumulation of fat in their muscles, and ultimately help to design appropriate
interventions to prevent type 2 Diabetes.
Inclusion Criteria:
- Body mass index (BMI): < 25 kg/m2 or > 30 kg/m2;
- Insulin sensitivity index (ISI): insulin-sensitive ISI ≥ 7, insulin-resistant ISI ≤ 5.
Exclusion Criteria:
- Medication or supplements known to affect either endothelial function or lipid
metabolism (i.e. arginine, protein, fish oil)
- Acute illness
- Uncontrolled metabolic disease, including liver or renal disease
- Atrial fibrillation, history of syncope, limiting or unstable angina, congestive heart
failure, known or suspected right-to-left, bi-directional or transient right-to-left
cardiac shunts
- Cardiac pacemaker or other medical device implanted in the body
- Pulmonary hypertension or other unstable cardiopulmonary conditions
- ECG documented abnormalities or valvular disease
- Low hemoglobin or hematocrit (i.e., lower than accepted laboratory values)
- History of hypertension or elevated blood pressure (systolic, >140 mmHg or a
diastolic, >95 mmHg)
- History of hyperlipidemia or plasma triglyceride concentration >200 mg/dl
- Diagnosed diabetes, or 2-h plasma glucose >200 mg/dl during an oral glucose tolerance
test
- Current participation in a weight-loss regimen, including extreme dietary practices
- Use of anabolic steroids or corticosteroids (within 3 months)
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