Prostate Cancer Screening and Dietary Heterocyclic Amines in African American Men

Conditions:Prostate Cancer, Cancer
Therapuetic Areas:Oncology
Age Range:50 - 70
Start Date:March 2002

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Prostate Cancer Screening and Dietary HA Exposure in African-Americans: Phase II

RATIONALE: Screening may help doctors find prostate cancer sooner, when it may be easier to
treat. The amount of heterocyclic amines in the diet may affect prostate cancer screening
results and the risk of prostate cancer.

PURPOSE: This phase II trial is studying prostate cancer screening and dietary heterocyclic
amines in African American men.


- Estimate dietary heterocyclic amine (HA) exposure in African American men who use
HA-forming meats and cooking methods.

- Correlate dietary HA exposure with prostate-specific antigen and digital rectal exam
screening results (i.e., higher HA exposure with increased abnormality in prostate
cancer screening results) in these participants.

OUTLINE: This is a prospective study.

Participants complete a routine medical questionnaire and undergo a detailed dietary
interview that focuses on meat consumption, cooking preferences, and other factors that may
be associated with prostate cancer risk. Participants then undergo a digital rectal exam
(DRE) and blood collection for prostate-specific antigen (PSA) testing (total PSA and % free
PSA). Results of PSA testing and DRE, including follow-up instructions (if needed), are sent
to the participant 3-4 weeks later.

Blood samples are also examined by phenotypic assays for UV-damage induced nucleotide
excision-repair capacity.

PROJECTED ACCRUAL: A total of 800 participants will be accrued for this study.


- African American male

- No previous diagnosis of prostate cancer

- Desires prostate cancer screening as a routine preventative medical service


- Lives in or near Oakland, California

- Speaks English

- No medical or other disability (e.g., blindness, psychological dysfunction, or
amputation) that would preclude study participation


- Not specified
We found this trial at
350 Hawthorne Ave
Oakland, California 94609
(510) 655-4000
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Oakland, CA
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