The Contribution of Incretin Hormones to Post-prandial Glucose Metabolism After Roux-en-Y Gastric Bypass
| Status: | Completed |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 20 - 70 |
| Updated: | 11/30/2013 |
| Start Date: | March 2012 |
| End Date: | September 2013 |
| Contact: | Paula Giesler, R.N. |
| Email: | giesler.paula@mayo.edu |
| Phone: | 507-255-8345 |
The study is being undertaken to understand how the Roux-en-Y Gastric Bypass procedure can
affect insulin secretion after meals. The hypothesis of this study is the Disposition Index
is decreased in subjects who had previously undergone Roux-en-Y Gastric Bypass by
glucagon-like peptide-1 (GLP-1) receptor blockade.
Inclusion Criteria Roux-en-Y Gastric Bypass (RYGB)Subjects:
- Subjects who have undergone RYGB
Inclusion Criteria Healthy Subjects:
- Must match RYGB subjects in age, weight, and gender
- Subjects will be without active systemic illness
Exclusion Criteria all Subjects:
- Subjects <20 years old and >70 years old
- For Female Subjects: positive pregnancy text at the time of enrollment or study
- Subjects with functional or organic bowel symptoms.
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