Monitoring of Neoadjuvant Therapy in Locally-Advanced Breast Cancer
| Status: | Terminated |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | September 2006 |
| End Date: | September 2015 |
The purpose of this study is to determine whether four new alternative imaging methods can
be used to follow the response of breast cancer to the treatment patients are being given.
These methods produce an image of the inside of the breast so that doctors can better decide
whether breast cancer is responding to therapy. An important part of the study is to examine
the same person with all methods in order to directly compare results. The four methods are:
MRI Elasticity Imaging (abbreviated MRE), Electrical Impedance Spectroscopy (abbreviated
EIS), Microwave Imaging and Spectroscopy (abbreviated MIS), Near Infrared Spectroscopy
(abbreviated NIR). In addition to the experimental imaging methods, patients may also
undergo a contrast-enhanced MRI, and/or additional mammography, which will help researchers
compare the experimental methods. These additional examinations are accepted diagnostic
procedures; they are not experimental. Some participants will have one or both of these
additional examinations if clinically indicated.
be used to follow the response of breast cancer to the treatment patients are being given.
These methods produce an image of the inside of the breast so that doctors can better decide
whether breast cancer is responding to therapy. An important part of the study is to examine
the same person with all methods in order to directly compare results. The four methods are:
MRI Elasticity Imaging (abbreviated MRE), Electrical Impedance Spectroscopy (abbreviated
EIS), Microwave Imaging and Spectroscopy (abbreviated MIS), Near Infrared Spectroscopy
(abbreviated NIR). In addition to the experimental imaging methods, patients may also
undergo a contrast-enhanced MRI, and/or additional mammography, which will help researchers
compare the experimental methods. These additional examinations are accepted diagnostic
procedures; they are not experimental. Some participants will have one or both of these
additional examinations if clinically indicated.
Inclusion Criteria:
1. Locally advanced breast cancer, with or without metastatic disease
2. Patient to receive systemic therapy
3. Breast size and epithelial integrity adequate to allow alternate imaging exams.
4. Patient able to provide written informed consent.
5. No serious associated psychiatric illness
6. Age ≥ 18 years old
Exclusion Criteria:
1. Cardiac pacemaker
2. Any implanted electronic device
3. Severe claustrophobia
4. Allergy to the MRI contrast agent gadolinium
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