Muscle Protein Metabolism in Obesity
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 8/24/2018 |
| Start Date: | October 2012 |
| End Date: | July 1, 2019 |
Regulation of Muscle ATP Synthase Beta Subunit Metabolism in Obesity
Obesity is associated with reduced adenosine triphosphate (ATP) turnover in skeletal muscle,
a condition that can impair muscle metabolism. The proposed research will discover mechanisms
responsible for decreased content in mitochondrial proteins as well as in protein
β-F1-ATPase, which is directly responsible for ATP assembly, in the muscle of obese
individuals. This research will further examine the effectiveness of interventions, such as
increased plasma amino acid availability and exercise, to increase the rate of production of
mitochondrial proteins as well as that of β-F1-ATPase in the muscle of obese individuals. The
findings will help to develop appropriate interventions to improve muscle ATP turnover and
metabolism in obese people.
a condition that can impair muscle metabolism. The proposed research will discover mechanisms
responsible for decreased content in mitochondrial proteins as well as in protein
β-F1-ATPase, which is directly responsible for ATP assembly, in the muscle of obese
individuals. This research will further examine the effectiveness of interventions, such as
increased plasma amino acid availability and exercise, to increase the rate of production of
mitochondrial proteins as well as that of β-F1-ATPase in the muscle of obese individuals. The
findings will help to develop appropriate interventions to improve muscle ATP turnover and
metabolism in obese people.
Inclusion criteria:
1. Body mass index (BMI): lean, 19-26 kg/m2; obese, 30-40 kg/m2
2. Availability of transportation
3. Ability to sign informed consent form
Exclusion criteria:
1. Medication or supplements (i.e. amino acids, protein) known to affect protein
metabolism
2. Presence of acute illness
3. History of liver disease
4. Uncontrolled metabolic disease
5. ECG documented abnormalities, atrial fibrillation, history of syncope, limiting or
unstable angina, or congestive heart failure
6. Chronically elevated blood pressure (systolic, >140 mmHg; diastolic, >100 mmHg)
7. Cardiac pacemaker or other medical device implanted in the body
8. Low hemoglobin or hematocrit
9. Current participation in a weight-loss regimen, including extreme dietary practices
10. Smoking
11. Use of anabolic steroids or corticosteroids (within 3 months)
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