Methodology Issues in a Tailored Light Treatment for Persons With Dementia

In a within subjects, randomized placebo control study, a tailored light treatment will be
used for short-term (4 weeks). Outcome measures include sleep measures (actigraphy), and
questionnaires probing behavior and mood in those who have been diagnosed with Alzheimer's
disease and related dementia. After a 4-week washout period, a placebo control inactive light
will be used for another 4 weeks.

Inclusion Criteria:

- mild to moderate Alzheimer's disease and related dementia (ADRD) based on National
Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's
Disease and Related Disorders Association (NINCDS-ADRDA) criteria,

- Clinical Dementia Rating (CDR) of 1 to 2,

- Mini-Mental State Examination (MMSE) between 8 and 24

Exclusion Criteria:

- major organ failure,

- major illness,

- history of head injury,

- hypertension or diabetes,

- use psychotropic (sleep aid) medicine, obstructing cataracts, macular degeneration,
and blindness