Interactive Effects of IV Ethanol and IV Nicotine

Conditions:Healthy Studies
Therapuetic Areas:Other
Age Range:21 - 50
Start Date:February 22, 2013
End Date:June 2014

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A Laboratory Study on the Interactive Effects of IV Ethanol and IV Nicotine on Subjective Effects and Cognition

There are mixed reports on nicotine's effects on ethanol-induced impairment in cognitive
performance and behavior in humans. The main objective of this study is to characterize the
interactive effects of acute intravenous (IV) ethanol and nicotine administration on
cognition and behavior in healthy smokers. The general hypothesis is that nicotine will
attenuate the negative effects of ethanol on cognition and subjective stimulant/sedative
effects of ethanol.

Inclusion Criteria:

1. Male and female;

2. between the ages of 21 and 50 years;

3. medically and neurologically healthy on the basis of history, physical examination,
EKG, screening laboratories

4. history of smoking daily for the past 12 months, at least 5 cigarettes daily; not
seeking treatment for nicotine dependence

5. social drinkers no maximum level of alcohol consumption will be defined a priori but
individuals who met current DSM -IV criteria for alcohol dependence (abuse will be
allowed) will be excluded from the study.

Exclusion Criteria:

1. history of major medical illnesses that the physician investigator deems as
contraindicated for the patient to be in the study;

2. regular use of psychotropic medication (antidepressants, antipsychotics, or
anxiolytics) and recent psychiatric diagnosis and treatment for Axis I disorders
including major depression, bipolar affective disorder, schizophrenia or panic

3. current abuse of any recreational or prescription drugs (except alcohol);

4. alcohol naïve.
We found this trial at
West Haven, Connecticut 06516
West Haven, CT
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