Interactive Effects of IV Ethanol and IV Nicotine

Inclusion Criteria:

1. Male and female;

2. between the ages of 21 and 50 years;

3. medically and neurologically healthy on the basis of history, physical examination,
EKG, screening laboratories

4. history of smoking daily for the past 12 months, at least 5 cigarettes daily; not
seeking treatment for nicotine dependence

5. social drinkers no maximum level of alcohol consumption will be defined a priori but
individuals who met current DSM -IV criteria for alcohol dependence (abuse will be
allowed) will be excluded from the study.

Exclusion Criteria:

1. history of major medical illnesses that the physician investigator deems as
contraindicated for the patient to be in the study;

2. regular use of psychotropic medication (antidepressants, antipsychotics, or
anxiolytics) and recent psychiatric diagnosis and treatment for Axis I disorders
including major depression, bipolar affective disorder, schizophrenia or panic
disorder;

3. current abuse of any recreational or prescription drugs (except alcohol);

4. alcohol naïve.