Evaluation of Mitochondrial Dysfunction in Severe Burn and Trauma Patients
| Status: | Recruiting |
|---|---|
| Conditions: | Other Indications, Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 19 - 70 |
| Updated: | 4/21/2016 |
| Start Date: | September 2011 |
| End Date: | December 2016 |
| Contact: | William O. Richards, MD |
| Email: | brichards@usouthal.edu |
| Phone: | 251-471-7993 |
The purpose of this project is to evaluate the level of mitochondrial dysfunction several
patient populations: Burn, trauma, and control group of healthy volunteers.
Study hypothesis: Increased plasma concentrations of a newly discovered inflammatory
mediated, called mtDNA DAMPS associated with the occurrence of multi-organ dysfunction
syndrome in severly injured patients.
As the severity of a burn injury or trauma injury increase, so will systemic mitochondrial
dysfunction.
patient populations: Burn, trauma, and control group of healthy volunteers.
Study hypothesis: Increased plasma concentrations of a newly discovered inflammatory
mediated, called mtDNA DAMPS associated with the occurrence of multi-organ dysfunction
syndrome in severly injured patients.
As the severity of a burn injury or trauma injury increase, so will systemic mitochondrial
dysfunction.
Increased plasma concentrations of a newly discovered inflammatory mediated, called mtDNA
DAMPS associated with the occurrence of multi-organ dysfunction syndrome in severly injured
patients.
A normal healthy sub-population will be used as a control.
DAMPS associated with the occurrence of multi-organ dysfunction syndrome in severly injured
patients.
A normal healthy sub-population will be used as a control.
Inclusion Criteria:
- Burn injury must be less than 24 hours old at time of initial sampling
- Burn must be 2nd or 3rd degree and at least 10% TBSA
- ISS (injury severity score) > 15
Exclusion Criteria:
- Burn injury/trauma injury > than 24hours old at time of initial sampling
- Burn < 10% total body surface area.
- Evidence of active infection on admission in the burn subjects.
- < 19 years of age and > 70 years
We found this trial at
1
site
Mobile, Alabama 36604
Principal Investigator: William O. Richards, MD
Phone: 251-471-7993
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