Evaluating the Safety and Pharmacokinetics of ABT-414 for Subjects With Glioblastoma Multiforme



Status:Completed
Conditions:Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 99
Updated:7/8/2017
Start Date:April 2, 2013
End Date:June 19, 2017

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A Phase 1 Study Evaluating the Safety and Pharmacokinetics of ABT-414 for Subjects With Glioblastoma Multiforme

This study is evaluating the safety and pharmacokinetics of ABT-414 in subjects with
glioblastoma multiforme.


Inclusion Criteria:

1. Glioblastoma Multiforme (GBM)

2. 70 or above on Karnofsky Performance Status

3. Adequate bone marrow function

4. Recurrent GBM per RANO criteria

5. Subjects must have confirmed EGFR amplification by central lab

Exclusion Criteria:

1. For Subjects with recurrent GBM in Arm B, subject has received prior treatment with
bevacizumab, nitrosourea, or has secondary GBM

2. For Subjects with recurrent GBM in Arm C, subject has received prior treatment with
bevacizumab, or has secondary GBM

3. Allergies to temozolomide, dacarbazine, IgG containing agents

4. Anti-cancer treatment 28 days prior to study Day 1, except in Arm B expanded cohort
temozolomide therapy is allowed

5. Subjects that have had more than one disease recurrence
We found this trial at
13
sites
388 Commonwealth Avenue
Boston, Massachusetts 02215
2576
mi
from 91732
Boston, MA
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1720 2nd Avenue South
Birmingham, Alabama 35294
1785
mi
from 91732
Birmingham, AL
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Boston, Massachusetts 02215
2576
mi
from 91732
Boston, MA
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7197
mi
from 91732
Brisbane,
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303 East Superior Street
Chicago, Illinois 60611
1730
mi
from 91732
Chicago, IL
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Detroit, Michigan 48202
1965
mi
from 91732
Detroit, MI
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1301 Central St
Evanston, Illinois 60201
1728
mi
from 91732
Evanston, IL
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1515 Holcombe Boulevard
Houston, Texas 77030
1357
mi
from 91732
Houston, TX
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Los Angeles, California 90095
24
mi
from 91732
Los Angeles, CA
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2435
mi
from 91732
New York, NY
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Salt Lake City, Utah 84112
572
mi
from 91732
Salt Lake City, UT
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4383 Medical Drive
San Antonio, Texas 78229
1182
mi
from 91732
San Antonio, TX
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505 Parnassus Avenue
San Francisco, California 94143
356
mi
from 91732
San Francisco, CA
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