A Phase 2 Multi-Center Study To Evaluate The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist In Adults With Type 2 Diabetes And Overt Nephropathy



Status:Completed
Conditions:Diabetic Neuropathy, Renal Impairment / Chronic Kidney Disease, Diabetes
Therapuetic Areas:Endocrinology, Nephrology / Urology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:December 2012
End Date:September 2014

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A Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel Group, Multi-center Study To Evaluate The Efficacy And Safety Of Once-daily Administration Of A Chemokine Ccr2/5 Receptor Antagonist (Pf-04634817) In Adults With Type 2 Diabetes And Overt Nephropathy

The study hypothesis under test is that administration of a CCR2/5 antagonist to subjects
with type 2 diabetes and overt nephropathy will result in a reduction in urinary albumin, a
surrogate for improved glomerular filtration.


Inclusion Criteria:

- Clinical diagnosis of type 2 diabetes together with stages 2, 3a, 3b or 4 CKD, based
on an eGFR of 20-75 mL/min/1.73m2.

- Evidence of persistent, overt albuminuria; defined as a UACR >=300 mg/g (>=33.9
mg/mmol) or UPCR >=390 mg/g (44.1 mg/mmol), or equivalent, for 3 months or longer.

- Stable background therapy of RAAS inhibition (ie, an ACE inhibitor and/or an ARB,
which may also include an aldosterone antagonist in double RAAS but not triple RAAS
inhibitor therapy) for at least 3 months before screening and to be maintained for
the duration of the study.

Exclusion Criteria:

- Subjects with CKD resulting from type 1 diabetes or non-diabetic CKD.

- Subjects who are diagnosed with autosomal dominant polycystic kidney disease
(ADPCKD), severe peripheral vascular disease (PVD) or obstructive uropathy.
We found this trial at
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North Hollywood, California 91606
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1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
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Pembroke Pines, Florida 33028
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593 Eddy Street
Providence, Rhode Island 02903
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Albuquerque, New Mexico 87109
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Flint, Michigan 48504
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Greenville, North Carolina 27834
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