Weight Loss Study-Mechanism Underlying the Improvement of Insulin Resistance in Response to Weight Loss
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 4/21/2016 |
| Start Date: | September 2012 |
| End Date: | November 2017 |
The main purpose of this study is to assess factors mediating the changes in insulin
sensitivity and glucose tolerance before and after 10 lbs ± or 2% weight loss reduction as
well as 2, 3, 6, 12, and 24 months after initiation of a low calorie diet.
The investigators will also study the following:
1. The impact of diet induced weight loss on hormones/adipokine levels
2. The impact of diet induced weight loss on leptin tolerance
sensitivity and glucose tolerance before and after 10 lbs ± or 2% weight loss reduction as
well as 2, 3, 6, 12, and 24 months after initiation of a low calorie diet.
The investigators will also study the following:
1. The impact of diet induced weight loss on hormones/adipokine levels
2. The impact of diet induced weight loss on leptin tolerance
Inclusion Criteria for interventional group:
1. Adult men and women, age 18-50
2. English speaking
3. Body mass index (pre weight loss) ≥30 kg/m2 but <40 kg/m2
4. Willing to enroll in a low calorie full meal replacement weight loss program
5. Willing and able to take part in a multi year study involving visits
Inclusion Criteria for control group:
1. Adult men and women, age 18-50
2. English speaking
3. Body mass index (pre weight loss) ≥30 kg/m2 but <40 kg/m2
4. Willing and able to take part in a multi year study involving visits
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