Effect of Weight & Insulin Sensitivity on Reproductive Function in PCOS: Studies in Skeletal Muscle & Adipose
| Status: | Completed |
|---|---|
| Conditions: | Ovarian Cancer, Neurology, Women's Studies, Endocrine |
| Therapuetic Areas: | Endocrinology, Neurology, Oncology, Reproductive |
| Healthy: | No |
| Age Range: | 20 - 40 |
| Updated: | 5/26/2018 |
| Start Date: | May 2012 |
| End Date: | April 2016 |
Effect of Weight and Insulin Sensitivity on Reproductive Function in Polycystic Ovary Syndrome: Studies in Skeletal Muscle and Adipose Tissue 'PULSE Ancillary Study'
The purpose of the study is to test in 52 overweight and obese women with polycystic ovary
syndrome the effect of 6 months of treatment with either: exercise training, 25% dietary
restriction or metformin in comparison to a control group receiving no intervention on the
functions of the skeletal muscle and adipose tissue.
syndrome the effect of 6 months of treatment with either: exercise training, 25% dietary
restriction or metformin in comparison to a control group receiving no intervention on the
functions of the skeletal muscle and adipose tissue.
The PULSE Ancillary study will last about 7 months. Participants will one or two additional
procedures performed at baseline and during the week 24 testing.
These procedures include a fat biopsy, a muscle biopsy or both.
procedures performed at baseline and during the week 24 testing.
These procedures include a fat biopsy, a muscle biopsy or both.
Inclusion Criteria:
- Enrolled in PULSE
Exclusion Criteria:
- Withdraw from PULSE
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