Effect of Exercise-Induced Weight Loss on Energy Metabolism
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 2/27/2019 |
| Start Date: | December 2010 |
| End Date: | February 2015 |
E-MECHANIC Ancillary Study: Effect of Exercise-Induced Weight Loss on Energy Metabolism
The E-MECHANIC Ancillary Study will measure changes in 24-hour energy expenditure and
spontaneous physical activity in a subset of 60 obese individuals enrolled in the main study.
We aim to determine if changes in energy metabolism might explain why people don't lose the
expected amount of weight in an exercise program.
spontaneous physical activity in a subset of 60 obese individuals enrolled in the main study.
We aim to determine if changes in energy metabolism might explain why people don't lose the
expected amount of weight in an exercise program.
This is an ancillary study to E-Mechanic, which is an National Institutes of Health study in
198 individuals with the objective to understand why certain people fail to lose weight in
exercise programs. In E-Mechanic changes in body weight, body composition, energy intake and
energy expenditure are measured before and after 3 different exercise programs of 24 weeks in
duration. The 3 exercise programs being compared are self-directed exercise, low dose
exercise and high dose exercise. The goal of this ancillary study is to undertake
comprehensive assessments of energy metabolism in a metabolic chamber in a group of 60 obese
individuals enrolled in the main study. We will compare differences in the changes in 24h
energy expenditure and spontaneous physical activity between the 3 exercise programs. We will
also test if changes in energy metabolism might explain why people don't lose the expected
amount of weight after 24 weeks of exercise.
198 individuals with the objective to understand why certain people fail to lose weight in
exercise programs. In E-Mechanic changes in body weight, body composition, energy intake and
energy expenditure are measured before and after 3 different exercise programs of 24 weeks in
duration. The 3 exercise programs being compared are self-directed exercise, low dose
exercise and high dose exercise. The goal of this ancillary study is to undertake
comprehensive assessments of energy metabolism in a metabolic chamber in a group of 60 obese
individuals enrolled in the main study. We will compare differences in the changes in 24h
energy expenditure and spontaneous physical activity between the 3 exercise programs. We will
also test if changes in energy metabolism might explain why people don't lose the expected
amount of weight after 24 weeks of exercise.
Inclusion Criteria:
- Individuals enrolled in the E-MECHANIC main study (NCT#01264406) with a body mass
index (BMI) greater than or equal to 30 kg/m2.
Exclusion Criteria:
- Not enrolled in the E-MECHANIC main study (NCT#01264406).
- Have a body mass index (BMI) less than 30 kg/m2.
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