Genomic Profiling in Cancer Patients



Status:Recruiting
Conditions:Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:2/8/2019
Start Date:January 2013
End Date:January 2020
Contact:David Hyman, MD
Phone:646-888-4544

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The purpose of this study is to determine whether certain genes in cancer may be abnormal.
When a gene is abnormal this is called a mutation. Most mutations in cancer cells are not
inherited (passed down from parents) but happen after birth in the cancer itself. Most
cancers have many mutations. Some of these mutations are important for the cancer cells to
survive while others are not. The goal of this study is test cancer for certain mutations
using leftover tumor tissue from a previous surgery or biopsy. Participants will also be
asked to provide a tube of blood cheek (also known as a buccal) swab, or a saliva sample that
contains normal genes for comparison.

The purpose of Part B of this study is to:

Understand how genetic changes in tumor effect the chance of responding to experimental
cancer treatment. Understand how the genes in the tumor change overtime in response to
targeted cancer treatment.


Inclusion Criteria:

Part A:

- Patients with cancer or other related disorders

Part B:

- Patients successfully registered to Part A of (MSKCC IRB # 12-245)

- Prior written approval for patient consent obtained from Director of the Center fo
Molecular Oncology, or a Principal/Co-Principal Investigator of MSKCC IRB # 12-245.

Part C:

- Patient must be receiving ongoing care at MSK or an Alliance/Affiliate site.

- Patient must have successfully consented to Part A of this study.

Exclusion Criteria:

- Unwilling or unable to provide informed consent.
We found this trial at
15
sites
1275 York Ave
New York, New York 10021
(212) 639-2000
Principal Investigator: David Hyman, MD
Phone: 646-888-4544
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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3550 Jerome Avenue
Bronx, New York 10467
(718) 920-4321
Principal Investigator: Balazs Halmos, MD
Phone: 718-405-8404
Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
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Allentown, Pennsylvania 18105
Phone: 610-402-7880
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136 Mountainview Boulevard
Basking Ridge, New Jersey 07920
Phone: 646-888-4544
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234 East 149th Street
Bronx, New York 10451
Principal Investigator: Monica Reddy Muppidi, MD
Phone: 718-579-4977
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Brooklyn, New York
Phone: 718-245-2847
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650 Commack Road
Commack, New York 11725
Phone: 646-888-4544
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500 Westchester Avenue
Harrison, New York 10604
Phone: 646-888-4544
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Hartford, Connecticut 06102
Phone: 860-972-2803
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Jamaica, New York 11432
Phone: 718-883-4031
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Miami, Florida 33143
Phone: 305-595-2141
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Middletown, New Jersey 07748
Phone: 646-888-4544
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225 Summit Avenue
Montvale, New Jersey 07645
Phone: 646-888-4544
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New York, New York 10035
Phone: 646-422-4474
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Rockville Centre, New York 11570
Phone: 646-888-4544
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