Quality of Life in Patients With Clinically Localized Prostate Cancer Treated With Radiosurgery

Study Design (for example, hypothesis, research question, standard and experimental
procedures, special or unusual equipment or procedures):

The main goal of this study is to evaluate quality of life outcomes and changes in patient
reported symptoms (e.g. urinary, bowel and sexual function) in patients receiving SBRT
treatment for clinically localized prostate cancer. Validated quality of life questionnaires
will be administered in a deidentified, prospective fashion. Eligible subjects will be
patients undergoing SBRT treatment for prostate cancer.

Hypothesis: Patients undergoing SBRT will have similar cancer control and symptoms as men who
are treated with other radiation therapy modalities.

Primary objective: To evaluate quality of life outcomes (e.g. fatigue, urinary, bowel and
sexual function) for patients with clinically localized prostate cancer treated with SBRT.

Secondary objectives: Prospective data on cancer control and toxicity following SBRT for
clinically localized prostate cancer.

Inclusion Criteria:

- Histologically confirmed adenocarcinoma of prostate

- Signed study-specific consent

- Prostate Specific Antigen (PSA) within 60 days of registration

Exclusion Criteria:

- Prior pelvic radiotherapy

- Prior radical prostate surgery

- Medical or psychiatric illness that would interfere with treatment or follow up

- Implanted hardware adjacent to the prostate that would prohibit appropriate treatment
planning and/or treatment delivery