Newborn Screening for Critical Congenital Heart Disease
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Women's Studies |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Reproductive |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 5/3/2014 |
| Start Date: | March 2010 |
| End Date: | January 2014 |
| Contact: | Lindsay Falk, BSN |
| Email: | lindsayc@peds.ufl.edu |
| Phone: | 352-273-9615 |
The Efficacy of Newborn Screening for Critical Congenital Heart Disease
Previous studies have examined the usefulness of pulse oximetry or oxygen saturation to
screen for left-sided cardiac lesions. These studies have shown that the occurrence of
critical congenital cardiac malformations among asymptomatic newborns is high; the technique
of pulse oximetry is reliable for detection of ductal dependant left-sided lesions, simple
to operate(requires little time and can be done in the newborn nursery) and is cost
effective; there is effective follow-up test (heart ultrasound) and available interventions
have an effect on outcome for diagnosed newborns. The importance of this research project
is to examine the overall helpfulness of measuring oximetry in newborn infants using somatic
oximetry, as well ast to prepare for a population based study in the state of Florida.
screen for left-sided cardiac lesions. These studies have shown that the occurrence of
critical congenital cardiac malformations among asymptomatic newborns is high; the technique
of pulse oximetry is reliable for detection of ductal dependant left-sided lesions, simple
to operate(requires little time and can be done in the newborn nursery) and is cost
effective; there is effective follow-up test (heart ultrasound) and available interventions
have an effect on outcome for diagnosed newborns. The importance of this research project
is to examine the overall helpfulness of measuring oximetry in newborn infants using somatic
oximetry, as well ast to prepare for a population based study in the state of Florida.
This study will evaluate up to 50 unaffected newborns and up to 10 known congenital heart
disease (CHD) newborns using a new oximetry system. This system is interfaced to a laptop
computer which computes the difference between central and lower extremity peripheral
values, upper and lower body peripheral values, and records all data. This information may
differentiate unaffected newborns and CHD newborns, and determine the effectiveness of pulse
oximetry as a newborn screening for congenital cardiovascular malformations.
disease (CHD) newborns using a new oximetry system. This system is interfaced to a laptop
computer which computes the difference between central and lower extremity peripheral
values, upper and lower body peripheral values, and records all data. This information may
differentiate unaffected newborns and CHD newborns, and determine the effectiveness of pulse
oximetry as a newborn screening for congenital cardiovascular malformations.
Inclusion Criteria:
- Male or female subjects aged 12 hours -2 weeks.
- Newborns with identified congenital heart disease or newborns without identified
congenital heart disease.
- Congenital Heart Diagnosis: Total Anomolous Pulmonary Venous Return (TAPVR);
Atrio-ventricular Septal Defect ( AVSD); Coarctation of the Aorta; Critical Aortic
Stenosis; other cyanotic legions including Hypoplastic Left Heart Syndrome ( HLHS)
Exclusion Criteria:
- Have any concurrent condition which, in the opinion of the investigator, would make
the subject unsuitable for the study.
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