Oral Antibiotics After 2-Stage Revision for Infected Total Hip Arthroplasty and Total Knee Arthroplasty



Status:Recruiting
Conditions:Infectious Disease, Orthopedic
Therapuetic Areas:Immunology / Infectious Diseases, Orthopedics / Podiatry
Healthy:No
Age Range:18 - 90
Updated:6/10/2018
Start Date:July 2011
End Date:December 2020
Contact:Craig J Della Valle, MD
Email:craigdv@yahoo.com
Phone:3124322350

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The Utility of Oral Antibiotic Therapy Following 2-stage Revision Arthroplasty for Infected Prosthetic Hips and Knees

The primary purpose of this study is to compare the re-infection rates in patients undergoing
2-stage revision arthroplasty who receive additional oral antibiotic therapy to those
patients who received in-hospital perioperative antibiotic only. Patients will be monitored
for re-infection following hospital discharge, defined as deep infection of the joint
space/capsule that requires return to the operating room within 24-months of the
re-implantation procedure.


Inclusion criteria:

Adult patients undergoing 2-stage revision arthroplasty of the knee or hip with the
causative organism(s) identified using tissue culture and/or joint fluid analysis that is
amenable to oral antibiotic therapy. Patients must be able to tolerate oral antibiotics and
agree to participate in the study.

Exclusion criteria:

Patients with a fungal prosthetic joint infection, unable to tolerate or refuse to undergo
oral antibiotic therapy, unable to follow-up at the specified intervals, allergic to the
therapy of preference, or have an organism that is not amenable to oral antibiotic therapy.
We found this trial at
4
sites
Philadelphia, Pennsylvania 19107
Principal Investigator: Javad Parvizi, MD, FRCS
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1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Principal Investigator: Craig J Della Valle, MD
Phone: 312-432-2468
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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Nashville, Tennessee 37212
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Winfield, Illinois 60190
Principal Investigator: Scott M Sporer, MD, MS
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Winfield, IL
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