Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment



Status:Terminated
Conditions:Cervical Cancer, Ocular
Therapuetic Areas:Oncology, Ophthalmology
Healthy:No
Age Range:18 - Any
Updated:7/13/2016
Start Date:October 2012

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A Randomized, Double-masked, Placebo-controlled Study of the Safety and Efficacy of Gevokizumab in the Treatment of Subjects With Non-infectious Intermediate, Posterior, or Pan-uveitis Currently Controlled With Systemic Treatment

The purpose of this study is to evaluate the efficacy of gevokizumab in reducing the risk of
recurrent uveitic disease in subjects with non-infectious uveitis whose disease is currently
controlled with systemic treatment.


Inclusion Criteria:

- Diagnosis of non-infectious intermediate, posterior, or pan- uveitis in at least one
eye

- Controlled uveitic disease in both eyes

- Stable dose of oral corticosteroids in combination with selected stable
immunosuppressive therapy

- Effective contraceptive measures

Exclusion Criteria:

- Infectious uveitis and masquerade syndromes

- Isolated anterior uveitis

- Contraindication to mydriatics

- Active tuberculosis disease

- History of allergic or anaphylactic reactions to monoclonal antibodies

- History of recurrent infection or predisposition to infection; active ocular
infection

- Pregnant or nursing women

Other protocol-defined inclusion/exclusion criteria may apply
We found this trial at
52
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Norfolk, VA
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Ashland, OR
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Belmont, NC
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Beverly Hills, California 90211
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Beverly Hills, CA
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Bloomfield, NJ
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Cambridge, MA
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Chandler, AZ
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Charlotte, North Carolina 28207
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Detroit, MI
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Ellsworth, ME
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Fargo, ND
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Golden, CO
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Houston, TX
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Olivos,
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Omaha, NE
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Palisades Park, New Jersey 07650
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San Luis Obispo, California 93405
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San Luis Obispo, CA
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Santa Ana, CA
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Teaneck, NJ
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Victorville, CA
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Washington,
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Winston-Salem, NC
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