Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment
| Status: | Terminated |
|---|---|
| Conditions: | Cervical Cancer, Ocular |
| Therapuetic Areas: | Oncology, Ophthalmology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/13/2016 |
| Start Date: | October 2012 |
A Randomized, Double-masked, Placebo-controlled Study of the Safety and Efficacy of Gevokizumab in the Treatment of Subjects With Non-infectious Intermediate, Posterior, or Pan-uveitis Currently Controlled With Systemic Treatment
The purpose of this study is to evaluate the efficacy of gevokizumab in reducing the risk of
recurrent uveitic disease in subjects with non-infectious uveitis whose disease is currently
controlled with systemic treatment.
recurrent uveitic disease in subjects with non-infectious uveitis whose disease is currently
controlled with systemic treatment.
Inclusion Criteria:
- Diagnosis of non-infectious intermediate, posterior, or pan- uveitis in at least one
eye
- Controlled uveitic disease in both eyes
- Stable dose of oral corticosteroids in combination with selected stable
immunosuppressive therapy
- Effective contraceptive measures
Exclusion Criteria:
- Infectious uveitis and masquerade syndromes
- Isolated anterior uveitis
- Contraindication to mydriatics
- Active tuberculosis disease
- History of allergic or anaphylactic reactions to monoclonal antibodies
- History of recurrent infection or predisposition to infection; active ocular
infection
- Pregnant or nursing women
Other protocol-defined inclusion/exclusion criteria may apply
We found this trial at
52
sites
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