CHOEP + High Dose Therapy + Auto SCT for T-Cell Lymphoma



Status:Terminated
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 70
Updated:4/21/2016
Start Date:February 2013
End Date:June 2015

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A Phase II Study of CHOEP Induction Followed by Gemcitabine/Busulfan/Melphalan Autologous Stem Cell Transplantation for Patients With Newly Diagnosed T-Cell Lymphoma

This is a phase II study of CHOEP induction chemotherapy followed by autologous stem cell
transplant using gemcitabine/busulfan/melphalan conditioning in patients with newly
diagnosed systemic T-cell non-Hodgkin lymphoma.

This is a phase II study of CHOEP (cyclophosphamide, doxorubicin, vincristine, etoposide and
prednisone)induction chemotherapy followed by autologous stem cell transplant using
gemcitabine/busulfan/melphalan conditioning in patients with newly diagnosed systemic T-cell
non-Hodgkin lymphoma. The study treatment comprises 6 cycles of CHOEP, followed (for
responding patients) by stem cell mobilization and harvesting (using neupogen +/-
plerixafor) followed by high dose therapy and autologous stem cell transplantation,

Inclusion Criteria:

- Diagnosis of T-Cell lymphoma with mandatory pathologic review at Brigham and Women's
Hospital or Massachusetts General Hospital

- Measurable disease

- Candidate for Autologous Stem Cell Transplant

Exclusion Criteria:

- Prior anti-lymphoma chemotherapy (except steroids/radiotherapy for urgent palliation,
one prior cycle of CHOP or up to 2 prior cycles of CHOEP)

- Pregnant or breastfeeding

- Alk-positive ACL

- Significant neuropathy precluding vincristine administration

- Known hypersensitivity to any of the agents used in the treatment

- Uncontrolled intercurrent illness

- Receiving other investigational agents

- History of a different malignancy except if disease free for at least 5 years or have
cervical cancer in situ or basal cell/squamous cell carcinoma of the skin

- HIV positive on anti-retroviral therapy
We found this trial at
2
sites
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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Boston, MA
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