Developing Anesthesia as Post Traumatic Stress Disorder (PTSD) Therapy
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology, Other |
| Healthy: | No |
| Age Range: | 18 - 35 |
| Updated: | 4/2/2016 |
| Start Date: | September 2009 |
| End Date: | April 2013 |
| Contact: | Michael T Alkire, MD |
| Email: | malkire@uci.edu |
| Phone: | 949 824 6128 |
Developing Anesthesia as PTSD Therapy
This preclinical phase 1 development study in healthy volunteers seeks to identify if low
doses of commonly used non-triggering anesthetic agents might have clinical utility for
modulating emotional memory processing and to understand the nature of the brain mechanisms
of drug action. Optimally, a drug, dose and brain mechanism of action will be identified
that will form the foundation for future use in clinical studies of patients with PTSD.
doses of commonly used non-triggering anesthetic agents might have clinical utility for
modulating emotional memory processing and to understand the nature of the brain mechanisms
of drug action. Optimally, a drug, dose and brain mechanism of action will be identified
that will form the foundation for future use in clinical studies of patients with PTSD.
Inclusion Criteria:
- Healthy adults.
- Between the ages of 18 and 35.
Exclusion Criteria:
- Pregnancy.
- Left-handed.
- Unusual facial anatomy.
- History of esophageal reflux.
- Respiratory problems.
- Central nervous system disorders.
- Cardiovascular problems.
- Kidney disease.
- Diabetes.
- History of Substance abuse.
- History of adverse anesthetic reactions.
- Hepatitis.
- Failure to pass MRI screening questionnaire.
- Fear of small-enclosed spaces.
- Mental illness.
- Non-native English speakers.
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