Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease



Status:Completed
Conditions:Alzheimer Disease, Neurology, Psychiatric
Therapuetic Areas:Neurology, Psychiatry / Psychology
Healthy:No
Age Range:50 - 95
Updated:4/21/2016
Start Date:November 2012
End Date:May 2015

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

A Prospective, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Efficacy and Safety Study of Oral ELND005 for Treatment of Agitation and Aggression in Patients With Moderate to Severe Alzheimer's Disease

The primary purpose of this study is to determine whether ELND005 is effective in treating
symptoms of agitation and aggression in patients with Alzheimer's disease


Inclusion Criteria:

- Diagnosis of Probable AD according to the National Institute on Aging- Alzheimer's
Association (NIA-AA) guidelines (McKhann et al 2011).

- MMSE score of 5 to 24 (inclusive) at the Screening Visit.

- Has clinically significant agitation/aggression defined as Neuropsychiatric Inventory
(NPI)-agitation/aggression subscore of ≥4.

- No response or suboptimal response to standard nonpharmacological interventions.

Exclusion Criteria:

- The agitation/aggression is attributable to concomitant medications, environmental
conditions, or active medical or psychiatric condition.

- Current diagnosis of major depressive disorder according to the criteria of the
Diagnostic and Statistical Manual of Mental Disorders Fourth Edition Text Revision
(DSM IV TR).

- Has persistent and distressing psychotic symptoms (delusion and/or hallucinations)
that require psychiatric hospitalization.
We found this trial at
58
sites
TransitionTIL Investigational Site
Orlando, Florida 32806
1144
mi
from
Orlando, FL
Click here to add this to my saved trials
TransitionTIL Investigational Site
Abington, Pennsylvania 19001
1227
mi
from
Abington, PA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Ann Arbor, Michigan 48105
806
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
TransitionTIL Investigational Site
Atlantis, Florida 33462
1287
mi
from
Atlantis, FL
Click here to add this to my saved trials
TransitionTIL Investigational Site
Bangor, Maine 04402
1575
mi
from
Bangor, ME
Click here to add this to my saved trials
TransitionTIL Investigational Site
Bellevue, Washington 98007
1402
mi
from
Bellevue, WA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Birmingham, Alabama 35294
683
mi
from
Birmingham, AL
Click here to add this to my saved trials
TransitionTIL Investigational Site
Calgary, Alberta
1214
mi
from
Calgary,
Click here to add this to my saved trials
TransitionTIL Investigational Site
Charlotte, North Carolina 28209
957
mi
from
Charlotte, NC
Click here to add this to my saved trials
TransitionTIL Investigational Site
Charlotte, North Carolina 28209
957
mi
from
Charlotte, NC
Click here to add this to my saved trials
TransitionTIL Investigational Site
Columbus, Georgia 31909
811
mi
from
Columbus, GA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Deerfield Beach, Florida 33064
1301
mi
from
Deerfield Beach, FL
Click here to add this to my saved trials
TransitionTIL Investigational Site
Delray Beach, Florida 33445
1293
mi
from
Delray Beach, FL
Click here to add this to my saved trials
TransitionTIL Investigational Site
DeSoto, Texas 75115
360
mi
from
DeSoto, TX
Click here to add this to my saved trials
TransitionTIL Investigational Site
Durham, North Carolina 27710
1051
mi
from
Durham, NC
Click here to add this to my saved trials
TransitionTIL Investigational Site
Easton, Maryland 21601
1179
mi
from
Easton, MD
Click here to add this to my saved trials
TransitionTIL Investigational Site
Encino, California 91316
1180
mi
from
Encino, CA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Escondido, California 92025
1128
mi
from
Escondido, CA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Fresno, California 93710
1206
mi
from
Fresno, CA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Hattiesburg, Mississippi 39401
657
mi
from
Hattiesburg, MS
Click here to add this to my saved trials
TransitionTIL Investigational Site
Irvine, California 92697
1156
mi
from
Irvine, CA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Jenkintown, Pennsylvania 19046
1227
mi
from
Jenkintown, PA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Lake Worth, Florida 33449
1281
mi
from
Lake Worth, FL
Click here to add this to my saved trials
TransitionTIL Investigational Site
Long Beach, California 90806
1172
mi
from
Long Beach, CA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Los Alamitos, California 90720
1164
mi
from
Los Alamitos, CA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Los Angeles, California 90073
1168
mi
from
Los Angeles, CA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Miami, Florida 33137
1321
mi
from
Miami, FL
Click here to add this to my saved trials
TransitionTIL Investigational Site
Nashville, Tennessee 37212
618
mi
from
Nashville, TN
Click here to add this to my saved trials
TransitionTIL Investigational Site
Newport Beach, California 92663
1161
mi
from
Newport Beach, CA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Norristown, Pennsylvania 19401
1215
mi
from
Norristown, PA
Click here to add this to my saved trials
TransitionTIL Investigational Site
North Charleston, South Carolina 29406
1054
mi
from
North Charleston, SC
Click here to add this to my saved trials
TransitionTIL Investigational Site
Norwalk, Connecticut 06851
1318
mi
from
Norwalk, CT
Click here to add this to my saved trials
TransitionTIL Investigational Site
Oakland Park, Florida 33334
1305
mi
from
Oakland Park, FL
Click here to add this to my saved trials
TransitionTIL Investigational Site
Oklahoma City, Oklahoma 73112
158
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
TransitionTIL Investigational Site
Ormond Beach, Florida 32174
1126
mi
from
Ormond Beach, FL
Click here to add this to my saved trials
TransitionTIL Investigational Site
Paw Paw, Michigan 49079
702
mi
from
Paw Paw, MI
Click here to add this to my saved trials
TransitionTIL Investigational Site
Philadelphia, Pennsylvania 19104
1225
mi
from
Philadelphia, PA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Philadelphia, Pennsylvania 19104
1225
mi
from
Philadelphia, PA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Phoenix, Arizona 85006
851
mi
from
Phoenix, AZ
Click here to add this to my saved trials
TransitionTIL Investigational Site
Phoenix, Arizona 85006
851
mi
from
Phoenix, AZ
Click here to add this to my saved trials
TransitionTIL Investigational Site
Pittsburgh, Pennsylvania 15213
971
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Port Charlotte, Florida 33952
1178
mi
from
Port Charlotte, FL
Click here to add this to my saved trials
TransitionTIL Investigational Site
Port Royal, South Carolina 29935
1035
mi
from
Port Royal, SC
Click here to add this to my saved trials
TransitionTIL Investigational Site
Portland, Oregon 97225
1383
mi
from
Portland, OR
Click here to add this to my saved trials
TransitionTIL Investigational Site
Richmond, Virginia 23230
1109
mi
from
Richmond, VA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Rochester, New York 14623
1120
mi
from
Rochester, NY
Click here to add this to my saved trials
TransitionTIL Investigational Site
Rochester, New York 14623
1120
mi
from
Rochester, NY
Click here to add this to my saved trials
TransitionTIL Investigational Site
Santa Ana, California 92701
1220
mi
from
Santa Ana, CA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Sarasota, Florida 34243
1138
mi
from
Sarasota, FL
Click here to add this to my saved trials
TransitionTIL Investigational Site
Savannah, Georgia 31419
1023
mi
from
Savannah, GA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Springfield, Illinois 62702
464
mi
from
Springfield, IL
Click here to add this to my saved trials
TransitionTIL Investigational Site
St. Paul, Minnesota 55130
556
mi
from
St. Paul, MN
Click here to add this to my saved trials
TransitionTIL Investigational Site
Stratford, New Jersey 08084
1233
mi
from
Stratford, NJ
Click here to add this to my saved trials
TransitionTIL Investigational Site
Sunrise, Florida 33351
1299
mi
from
Sunrise, FL
Click here to add this to my saved trials
TransitionTIL Investigational Site
Washington, District of Columbia 20057
1125
mi
from
Washington,
Click here to add this to my saved trials
TransitionTIL Investigational Site
Wilmington, North Carolina 28401
1135
mi
from
Wilmington, NC
Click here to add this to my saved trials
TransitionTIL Investigational Site
Winchester, Massachusetts 01890
1440
mi
from
Winchester, MA
Click here to add this to my saved trials
TransitionTIL Investigational Site
Winston-Salem, North Carolina 27103
971
mi
from
Winston-Salem, NC
Click here to add this to my saved trials