Does Doxazosin Attenuate Stress-induced Smoking and Improve Clinical Outcomes?



Status:Completed
Conditions:Smoking Cessation
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - 60
Updated:2/22/2018
Start Date:February 2013
End Date:November 2016

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The purpose of this study is to examine whether doxazosin will attenuate the ability of
stress to precipitate smoking lapse behavior in treatment seeking daily smokers. Participants
will participate in a smoking cessation attempt after the laboratory sessions.


Inclusion Criteria:

- Ages 18-60

- Able to read and write English

- Smoker

- Motivated to Quit Smoking

Exclusion Criteria:

- Any significant current medical conditions that would contraindicate smoking

- Current Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) abuse or
dependence of other substances, other than nicotine dependence or alcohol abuse

- Positive test results at intake appointment on urine drug screens for illicit drugs

- Past 30 day use of psychoactive drugs including anxiolytics and antidepressants

- Women who are pregnant or nursing

- Suicidal, homicidal or evidence of current severe mental illness such as
schizophrenia, bipolar disorder or major depression, or anxiety disorders

- Participants who have donated blood within the past 6 weeks

- Individuals who are currently taking other medications prescribed for smoking
cessation

- Specific exclusions for administration of doxazosin or any alpha blocker
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