Epigenetics and the Origin of Muscle Insulin Resistance in Humans



Status:Completed
Conditions:Obesity Weight Loss, Endocrine, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:21 - 55
Updated:1/17/2018
Start Date:August 2012
End Date:November 21, 2016

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The investigators are trying to understand the role of DNA (deoxyribonucleic acid)
methylation in insulin resistance in skeletal muscle and blood tissues. DNA methylation is a
normal chemical process in the body that modifies DNA. By studying this, the investigators
hope to better understand the causes of insulin resistance.

Insulin resistance is defined as the decreased ability of insulin to perform its biological
function in the muscle, liver and fat. Genetic and environmental factors are known to
influence insulin sensitivity. It is not known how this is mediated. This study looks at the
role of epigenetics (modifications of proteins associated with DNA and methylation of DNA) in
alterations in insulin resistance. We will study lean healthy people, obese non-diabetic
people and people with type 2 diabetes to characterize the DNA methylation patterns in muscle
in each group. The second aim of the study is to see how a single bout of exercise affects
the DNA methylation in the muscle. The third aim looks at the effect of 8 weeks of supervised
exercise on the DNA methylation.

Volunteers must be:

- 21 - 55 years old

- must be non-lactating, non-pregnant

- not taking medications known to affect glucose or if taking them, on stable doses.

- free of significant heart or lung disease
We found this trial at
1
site
13400 E. Shea Blvd.
Scottsdale, Arizona 85259
480-301-8000
Phone: 480-301-4626
Mayo Clinic Arizona Mayo Clinic in Arizona provides medical care for thousands of people from...
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