Doxorubicin Hydrochloride Liposome, Melphalan, and Bortezomib in Treating Patients With Relapsed or Refractory Stage I, Stage II, or Stage III Multiple Myeloma

Conditions:Cancer, Blood Cancer, Hematology
Therapuetic Areas:Hematology, Oncology
Age Range:18 - Any
Start Date:February 2006

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Phase I/II Study of Liposomal Doxorubicin (Doxil®)/ Melphalan/Bortezomib (Velcade®) in Relapsed/Refractory Multiple Myeloma

RATIONALE: Drugs used in chemotherapy, such as doxorubicin hydrochloride liposome and
melphalan, work in different ways to stop the growth of cancer cells, either by killing the
cells or by stopping them from dividing. Bortezomib may stop the growth of cancer cells by
blocking some of the enzymes needed for cell growth. Giving doxorubicin hydrochloride
liposome and melphalan together with bortezomib may kill more cancer cells.

PURPOSE: This phase I/II trial is studying the side effects and best dose of doxorubicin
hydrochloride liposome , melphalan, and bortezomib and to see how well they work in treating
patients with relapsed or refractory stage I, stage II, or stage III multiple myeloma.



- Determine the safety and tolerability of doxorubicin HCl liposome, melphalan, and
bortezomib in patients with relapsed or refractory stage I-III multiple myeloma.

- Determine the maximum tolerated dose (MTD) of this regimen in these patients.


- Determine the overall response rate, including complete, near-complete, partial, and
minimal response rate, in patients treated with this regimen.

- Determine the time to response, progression-free survival, and overall survival of
patients treated with this regimen.

- Determine the toxic effects of this regimen at the MTD in these patients.

OUTLINE: This is a multicenter, phase I, dose-escalation study followed by a phase II study.

- Phase I: Patients receive doxorubicin HCl liposome IV over 30-60 minutes and melphalan
IV over 30 minutes on day 1 and bortezomib IV on days 1, 4, 8, and 11. Treatment
repeats every 28 days for up to 6 courses in the absence of disease progression or
unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of doxorubicin HCl liposome, melphalan, and
bortezomib until the maximum tolerated dose (MTD) is determined. The MTD is defined as the
dose preceding that at which 2 of 3 or 4 of 6 patients experience dose-limiting toxicity
after 2 courses of therapy.

- Phase II: Patients receive doxorubicin HCl liposome, melphalan, and bortezomib at the
MTD as in phase I.

After completion of study treatment, patients are followed every 3 months.

PROJECTED ACCRUAL: Approximately 32 patients will be accrued for this study.


- Diagnosis of multiple myeloma

- Stage I, II, or III disease according to Durie-Salmon staging criteria

- Progressive disease, defined as one of the following:

- For secretory disease:

- A 25% increase in serum M-protein or Bence Jones protein (an absolute
increase of 0.5 g/dL serum M-protein or ≥ 200 mg/24 hours of urine light
chain excretion)

- For nonsecretory disease:

- Bone marrow biopsy with > 25% increase in plasma cells or an absolute
increase of ≥ 10% over prior known level

- Development of new or worsening existing lytic bone lesions or soft tissue

- Hypercalcemia (i.e., calcium > 11.5 mg/dL)

- Relapsed after complete response

- Must have received ≥ 2 of the following therapeutic regimens for multiple myeloma:

- Nonmyeloablative transplantation

- No significant graft-versus-host disease

- At least 30 days since prior immunosuppressive therapy (concurrent
prednisone allowed provided dose is ≤ 10 mg daily)

- Mobilization with chemotherapy followed by either single or tandem autologous
stem cell transplantation (considered 1 prior regimen)

- Mobilization with chemotherapy followed by autologous and subsequent
nonmyeloablative allogeneic stem cell transplantation (considered 1 prior

- Any combination of drugs given concurrently (considered 1 prior regimen)


- ECOG performance status 0-2

- Life expectancy ≥ 3 months

- Absolute neutrophil count > 1,000/mm^3 (no colony-stimulating factors)

- Platelet count > 50,000/mm^3 (no transfusion support)

- Bilirubin ≤ 2.0 mg/dL

- AST ≤ 4 times upper limit of normal

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for 4 weeks after
completion of study treatment

- No history of allergic reaction to compounds containing boron or mannitol

- No active uncontrolled viral (including HIV), bacterial, or fungal infection

- No motor or sensory neuropathy ≥ grade 2

- No myocardial infarction within the past 6 months

- No New York Heart Association class III or IV heart failure

- No uncontrolled angina

- No severe uncontrolled arrhythmia

- No acute ischemia by EKG

- LVEF ≥ 35% by MUGA (MUGA required in patients whose lifetime cumulative doxorubicin
hydrochloride dose > 400 mg/m^2)


- See Disease Characteristics

- No grade III or IV toxicity due to previous antineoplastic therapy (except alopecia)

- At least 3 weeks since prior chemotherapy

- No prior doxorubicin HCl liposome, melphalan, and bortezomib as combination therapy
(single or two-drug combinations of these are allowed)

- No concurrent corticosteroids (≤ 10 mg prednisone/day or equivalent allowed)

- No other concurrent chemotherapy

- No concurrent thalidomide

- No other concurrent investigational therapy

- No other concurrent antineoplastic treatment for multiple myeloma, including

- No concurrent radiation therapy

- No concurrent nonsteroidal anti-inflammatory agents
We found this trial at
701 West 168th Street
New York, New York 10032
(212) 851-4680
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center The Herbert Irving Comprehensive Cancer...
New York, NY
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1600 Divisadero Street
San Francisco, California 94115
UCSF Helen Diller Family Comprehensive Cancer Center UCSF’s long tradition of excellence in cancer research...
San Francisco, CA
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