The MURDOCK Study Registry and Biorepository Horizon 1.5

The MURDOCK Study Community Registry and Biorepository's activities include enrolling
approximately 50,000 participants who live in Cabarrus County and/or Kannapolis, North
Carolina. Participants must consent to (1) use of the data provided by the participant
through completion of the Participant Registry Questionnaire for epidemiologic population
characterization, (2) annual contact to update their MURDOCK Horizon 1.5 database record, (3)
release of their medical information, including but not limited to demographic information,
problem lists, medications, social and family history, and results of laboratory and other
testing modalities from pre-existing paper or electronic health records or electronic health
records that may become available in the future, (4) provision of a blood and urine sample,
and (5) contact up to four times/year to request participation in additional research
studies.

Inclusion Criteria:

1. A resident of Cabarrus County and/or the city of Kannapolis (and surrounding regions)
for 6 or more months of the year

2. At least 18 years of age

3. Able to understand and give written informed consent, or have a legal guardian or
caregiver present to give informed consent by proxy (assent from a participant between
ages 12-18 will be obtained when their parent or legal guardian consents on their
behalf).

4. Willing and able to participate in all 5 components of the registry and biorepository
as described above in Section III

Exclusion Criteria:

1. There are no exclusions to participation if all inclusion criteria have been met.