A Study of Ixekizumab in Participants With Active Psoriatic Arthritis



Status:Completed
Conditions:Arthritis, Psoriasis
Therapuetic Areas:Dermatology / Plastic Surgery, Rheumatology
Healthy:No
Age Range:18 - Any
Updated:1/10/2019
Start Date:December 2012
End Date:September 2017

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A Multicenter, Randomized, Double-Blind, Active and Placebo-Controlled 24-Week Study Followed by Long Term Evaluation of Efficacy and Safety of Ixekizumab (LY2439821) in Biologic Disease-Modifying Antirheumatic Drug-Naive Patients With Active Psoriatic Arthritis

This study will assess the safety and efficacy of ixekizumab (LY2439821) compared to placebo
in participants with active psoriatic arthritis.


Inclusion Criteria:

- Presents with established diagnosis of active psoriatic arthritis for at least 6
months, and currently meets Classification for Psoriatic Arthritis (CASPAR) criteria

- Active psoriatic arthritis (PsA) defined as the presence of at least 3 tender and at
least 3 swollen joints

- Presence of active psoriatic skin lesion or a personal history of plaque psoriasis
(Ps)

- Men must agree to use a reliable method of birth control or remain abstinent during
the study

- Women must agree to use reliable birth control or remain abstinent during the study
and for at least 12 weeks after stopping treatment

Exclusion Criteria:

- Current or prior use of biologic agents for treatment of Ps or PsA

- Inadequate response to greater than or equal to 4 conventional disease-modifying
antirheumatic drugs (DMARDs)

- Current use of more than one conventional DMARD

- Evidence of active inflammatory arthritic syndromes or spondyloarthropathies other
than PsA

- Have participated in any study with interleukin 17 (IL-17) antagonists, including
ixekizumab

- Serious disorder or illness other than psoriatic arthritis

- Serious infection within the last 3 months

- Breastfeeding or nursing (lactating) women
We found this trial at
38
sites
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Little Rock, AR
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Atlanta, GA
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Birmingham, AL
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Boca Raton, FL
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Brooklyn, NY
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Cedar Rapids, IA
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Charlotte, North Carolina 28207
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Charlotte, NC
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Clarksburg, West Virginia 26301
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Clarksburg, WV
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Columbia, SC
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Cumberland, MD
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Dallas, TX
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Dayton, OH
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Decatur, GA
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Duncansville, Pennsylvania 16635
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Duncansville, PA
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Durham, NC
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Genk,
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Greensboro, North Carolina 27401
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Greensboro, NC
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Hagerstown, MD
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Houston, TX
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Huntsville, AL
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Indianapolis, IN
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Jackson, TN
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Kennewick, WA
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Marietta, GA
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Orange Park, FL
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Orangeburg, SC
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Rochester, NY
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Saint Louis, MO
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Seattle, WA
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Spokane, WA
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Tampa, FL
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Toms River, NJ
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Tuscaloosa, AL
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Upland, CA
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Voorhees, NJ
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Wichita, KS
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Zephyrhills, FL
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