Intracoronary Imaging With NIRS-IVUS to Characterize Arterial Plaques

This study is being performed to characterize the composition and morphologic characteristics
of atherosclerotic coronary artery plaques with intra-coronary near-infrared spectroscopy and
intravascular ultrasound in patients undergoing percutaneous coronary intervention.

Inclusion Criteria:

1. Subject is at > 18 years of age

2. Subject presents to the catheterization laboratory to undergo clinically-indicated,
invasive coronary angiography

3. Subject is willing and able to provide informed written consent

4. Subject is found to have ≥ 1 severe coronary artery stenosis by invasive angiography
and percutaneous coronary intervention is planned for definitive treatment or found to
have ≥ 1 intermediate coronary artery stenosis and IVUS planned for lesion assessment

5. Coronary anatomy is deemed suitable for combined NIRS-IVUS by the interventional
cardiologist performing invasive angiography and intervention

Exclusion Criteria:

1. Subject is pregnant or suspected to be pregnant

2. Subject is unable to provide informed consent

3. Subject has coronary artery anatomy deemed by interventionalist as unsuitable for
NIRS-IVUS