Efficacy of Fascia Iliaca Block Versus Intraoperative Nerve Infiltration During Anterior Hip Replacement Surgery

Though still uncommonly used in the United States, the popularity of the anterior approach
for total hip replacement is rapidly growing because of its clinical advantages.
Rehabilitation is simplified and accelerated, dislocation risk is reduced, leg length is more
accurately controlled, and incision is smaller than with traditional approaches (GOEBEL).
Nevertheless, although pain is lessened, it is still considerable, and new techniques have
been developed to improve postoperative pain control for this procedure.

Surgical incision and tissue trauma result in postoperative pain. Regional pain blocks,
especially when done under ultrasound guidance, have proven to be extremely effective at
reducing postoperative pain and improving patient satisfaction. One such block, the fascia
iliaca compartment block (FICB), has been shown to be effective in controlling pain
associated with surgery involving the hip and femur.

Although possible without ultrasound guidance, using this technique allows for identification
of specific tissue planes and precise placement of medication near the nerves responsible for
postoperative pain. Using ultrasound, the superficial fascial layer of the iliopsoas muscle
is identified at the anterior edge of the ilium, and a needle is placed just beneath that
fascia. A high volume of local anesthetic is then injected under ultrasound guidance,
ensuring cephalad spread of medication, in an attempt to provide anesthesia of the lateral
femoral cutaneous, femoral and obturator nerves.

Unlike other approaches to hip replacement, anterior repair allows for direct visualization
of the fascial layers described above. This allows for direct injection of local anesthetic
beneath this fascia, potentially obviating the need for preoperatively performed, ultrasound
guided, FICB. The primary differences in approach (ultrasound guided preop versus direct
visualization intraop) is the timing of injection, and it is unclear if nerve block prior to
or after tissue damage affects postoperative pain in these patients.

Surgical trauma causes nerve sensitization leading to amplification and prolongation of
postoperative pain. In experimental studies, pre-injury neural blockade using local
anesthetics has been shown to reduce post-injury sensitization of the central nervous system,
while similar techniques applied after the injury had less or no effect (FILOS).
Investigators have therefore designed this study to examine the timing of FICB
(pre-operatively versus intra-operatively) on postoperative pain in patients undergoing
anterior hip replacement surgery.

Inclusion Criteria:

- Adults 18-65 years of age

- Female patients must be surgically sterile, postmenopausal or have a negative
pregnancy test on the day of surgery

- Willing and able to sign the informed consent approved by the Institutional Review
Board (IRB)

- Willing and able to complete the study procedures and pain scales, and to communicate
meaningfully in English with study personnel

- Elective anterior hip replacement to be performed at Beaumont Hospital, Royal Oak

- American Society of Anesthesiologists physical status classification 1, 2, and 3
(patients that have either no systemic illness, or mild to moderate systemic disease,
eg. asthma, diabetes or hypertension)

Exclusion Criteria:

- History of allergy to study medications including ropivacaine and other local
anesthetic agents of the amide-type

- Enrollment in concurrent research study

- Female patients who are pregnant or lactating, or who have a positive urine pregnancy
test

- Opioid tolerant, ie, A patient taking a narcotic > 30mg per day morphine equivalent.
(Source: www.globalrph.com/narcotic.cgi) for pain in the 2 months prior to surgery

- A medical condition that in the investigator's opinion could adversely impact the
patient's participation or safety, conducts of the study, or interferes with the pain
assessments

- Previous hip arthroplasty (partial or total) of the index hip

- History of illicit drug use, or prescription medicine or alcohol abuse within the past
2 years