Breast Milk and Infant Growth Among Lean, Overweight and Diabetic Mothers



Status:Recruiting
Conditions:Obesity Weight Loss, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:20 - 35
Updated:12/29/2018
Start Date:August 2012
End Date:September 2020
Contact:Nichole Hirsch, MS
Email:NICOLE.HIRSCH@UCDENVER.EDU
Phone:(303) 724-8966

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Breast Milk and Infant Growth and Body Composition Among Healthy Mothers, Obese Mothers, and Mothers With Diabetes

Childhood obesity is a critical global public health concern. Breastfeeding is the ideal
choice for infant nutrition. However, rapid and excess weight gain during infancy predicts
later, even among breastfed infants. This risk is higher if mothers are obese and/or
diabetic. Composition of bioactive components of breast milk may differ based between mothers
who are normal weight (NW), overweight, or who have diabetes. Obesity and Type 2 Diabetes are
associated with overall increases in inflammation and oxidative stress, but how breast milk
composition is affected remains unknown. The investigators overarching goal is to determine
how maternal obesity and Type 2 Diabetes impacts human breast milk composition and how
differences in composition may impact infant growth and fat development. The investigators
are undertaking a study that follows 20 Normal Weight, 20 Obese, 20 Gestational Diabetic, and
20 Type 2 Diabetic mothers and their infants over the first 4 months of life. The
investigators will track infant weight and fat gain and monitor maternal glucose control. The
investigators will also collect breast milk samples over the first 4 months and measure
concentrations of growth and appetite hormones, cytokines, markers of oxidative stress and
nutrient composition in milk. The investigators predict that concentrations of
growth-regulatory hormones (insulin and leptin) in addition to the inflammatory cytokines and
markers of oxidative stress will be lowest in breast milk from NW mothers, higher in breast
milk from obese and gestational diabetic mothers, and highest in Type 2 Diabetic mothers'
breast milk. The investigators expect these differences will be most pronounced in the first
2 weeks after birth. The investigators also predict that breast milk concentrations of these
biomarkers will be associated with infant fat gain. What the investigators find will help
understand how early infant nutrition and growth may affect that child's later risk of
obesity.


Inclusion Criteria:

- Between 28-40 weeks gestation

- Plan to Exclusively Breastfeed for at least 5 months

- Between 20 - 35 years old

- Carrying a singleton pregnancy

- Parity less than or equal to 5

- Pre-pregnancy BMI between 18.5 and 39.9

Exclusion Criteria:

- No known infant anomalies or birth defects

- Maternal Type 1 Diabetes

- Maternal major medical condition (ie: Kidney Disease or Pre-eclampsia)

- Delivery of the infant before 35 weeks gestation

- Smoking During pregnancy
We found this trial at
1
site
13001 E 17th Pl
Aurora, Colorado 80045
(303) 724-5000
Principal Investigator: Nancy F Krebs, MD, MS
Phone: 303-724-8966
University of Colorado Anschutz Medical Campus Located in the Denver metro area near the Rocky...
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Aurora, CO
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