Efficacy, Safety, and Tolerability of an Intramuscular Formulation of Aripiprazole (OPC-14597) as Maintenance Treatment in Bipolar I Patients



Status:Completed
Conditions:Psychiatric, Bipolar Disorder
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 65
Updated:8/26/2018
Start Date:August 2012
End Date:April 2016

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52-week, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of an Intramuscular Depot Formulation of Aripiprazole (OPC-14597) as Maintenance Treatment in Patients With Bipolar I Disorder

This will be a randomized, double-blind, placebo-controlled trial to assess the time to
recurrence of any mood episode in subjects with bipolar I disorder who have maintained
stability on aripiprazole IM depot for at least 8 weeks. This trial will include male and
female subjects 18 to 65 years of age, inclusive, with a diagnosis of bipolar I disorder,
according to DSM-IV-TR criteria and confirmed by the Mini International Neuropsychiatric
Interview (MINI), who have experienced at least one previous manic episode of sufficient
severity to require hospitalization and/or treatment with a mood stabilizer or antipsychotic
agent in addition to their current manic episode. All subjects must be experiencing a manic
episode (per DSM-IV-TR criteria) with a YMRS total score ≥ 20 at trial entry. Both inpatients
and outpatients are eligible for this trial.

This trial will consist of a screening phase followed by 4 treatment phases. Subjects will
undergo screening for eligibility, followed by a conversion to oral aripiprazole monotherapy
phase, if needed, an oral aripiprazole stabilization phase, a single-blind aripiprazole IM
depot stabilization phase, and, a double-blind, placebo-controlled phase.


Key Inclusion Criteria:

1. Male and female subjects 18 to 65 years of age, inclusive, at time of informed
consent.

2. Subjects with a current diagnosis of bipolar I disorder, as defined by DSM-IV-TR
criteria and confirmed by the MINI and a history of at least one previous manic or
mixed episode with manic symptoms of sufficient severity to require one of the
following interventions: hospitalization and/or treatment with a mood stabilizer,
and/or treatment with an antipsychotic agent, in addition to their current manic
episode. "Require" is defined as an intervention that occurred rather than one that
was recommended. Rapid cyclers with 8 or fewer episodes in the previous year will be
included.

3. Subjects currently experiencing a manic episode with a YMRS total score of ≥20 at the
Screening Visit.

4. Subjects can have an inpatient or outpatient status prior to entry into Phase C (IM
depot stabilization).

5. In the investigator's opinion, subjects who are able to understand the nature of the
trial and follow protocol requirements, including the prescribed dosage regimens,
tablet ingestion, aripiprazole IM depot injection, and discontinuation of prohibited
concomitant medications; who can read and understand the written word in order to
complete subject-reported outcomes measures; and who can be reliably rated on
assessment scales.

Key Exclusion Criteria:

1. Subjects with a current Axis I (DSM-IV-TR) diagnosis other than bipolar I disorder.

2. Subjects who have NOT experienced at least one previous manic or mixed episode with
manic symptoms of sufficient severity to require one of the following interventions:
hospitalization and/or treatment with a mood stabilizer, and /or treatment with an
antipsychotic agent, excluding their current manic episode. "Require" is defined as a
intervention that occurred rather than one that was recommended.

3. Subjects with bipolar I disorder who are considered resistant/refractory to treatment
for manic symptoms by history.

4. Subjects unresponsive to clozapine for treatment of mania.

5. Subjects with a significant risk of committing suicide based on history, mental status
examination, investigator's judgment, or C-SSRS answer of "yes" to question 4 or 5
(current or within the last 90 days).

6. Subjects with a current manic episode with a duration of > 2 years.

7. Subjects who currently (within the past month) meet DSM-IV-TR criteria for substance
abuse or substance dependence; this includes the abuse of alcohol and benzodiazepines,
but excludes the use of caffeine and/or nicotine.

8. Subjects who have a history or evidence of a medical condition that would expose them
to an undue risk of a significant adverse event (AE) or interfere with assessments of
safety or efficacy during the course of the trial, including but not limited to
hepatic, renal, respiratory, cardiovascular, endocrine, neurologic, hematologic, or
immunologic disease as determined by the clinical judgment of the investigator.

9. Subjects who are currently experiencing a mixed or a depressive episode (per DSM-IV-TR
criteria).

10. Subjects with a history of hypersensitivity to antipsychotic agents.
We found this trial at
43
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Hoffman Estates, Illinois 60194
1707
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Beverly Hills, California 90211
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Chatham,
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Flowood, MS
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Jenkintown, PA
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Lauderhill, FL
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Lincoln, NE
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Los Angeles, CA
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Melbourne, FL
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National City, California 91950
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National City, CA
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New Orleans, LA
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Pico Rivera, CA
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Richmond, VA
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Rockville, MD
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Saint Louis, MO
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San Diego, CA
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Springdale, AR
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Torrance, CA
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Wichita Falls, TX
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