Osteonecrosis of the Jaw (ONJ) Case Registry



Status:Active, not recruiting
Conditions:Orthopedic
Therapuetic Areas:Orthopedics / Podiatry
Healthy:No
Age Range:18 - Any
Updated:10/20/2018
Start Date:October 1, 2012
End Date:April 9, 2021

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Osteonecrosis of the Jaw (ONJ) Case Registry

The purpose of the ONJ case registry is to describe the natural history of
positively-adjudicated ONJ in subjects with cancer with an observation period of 5 years.
Most of these subjects are expected to have received bone antiresorptive agents such as
bisphosphonates or denosumab together with cancer-specific therapies (eg, chemotherapy,
steroids, or anti-angiogenics). It is also possible that the registry will include subjects
with cancer who developed ONJ without exposure to any antiresorptive therapy.

Inclusion Criteria:

- Adult (≥18 years of age) with diagnosis of cancer

- Newly diagnosed, positively-adjudicated ONJ

- ECOG <=2 and expected survival ≥3 months

- Willing to provide access to previous and future medical and dental information

- Subject or subject's legally acceptable representative has provided written informed
consent

Exclusion Criteria:

- History of radiation to the jaws administered for the treatment of cancer

- Subject will not be available for protocol required study visits, to the best of the
subject and investigator's knowledge.

- Subject has any kind of disorder that, in the opinion of the investigator, may
compromise the ability of the subject to give written informed consent and/or to
comply with all required study procedures.
We found this trial at
23
sites
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mi
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Council Bluffs, IA
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mi
from
Atlanta, GA
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mi
from
Baltimore, MD
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Beverly Hills, California 90211
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mi
from
Beverly Hills, CA
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mi
from
Bruxelles,
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mi
from
Buffalo, NY
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mi
from
Buffalo, NY
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Charlotte, North Carolina 28207
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mi
from
Charlotte, NC
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mi
from
Chicago, IL
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mi
from
Cleveland, OH
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mi
from
Denver, CO
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mi
from
Duarte, CA
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mi
from
Farmington, CT
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mi
from
Gainesville, FL
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mi
from
Houston, TX
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mi
from
Memphis, TN
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mi
from
Mineola, NY
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mi
from
Nashville, TN
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mi
from
Omaha, NE
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mi
from
Omaha, NE
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mi
from
Philadelphia, PA
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mi
from
Stratford, CT
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mi
from
Washington,
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