Cryo-Touch III Refinement Study Investigational Plan

Inclusion Criteria:

- Age 30-70 years

- Subject has a glabellar and/or forehead wrinkle rating by investigator of at least 2
in animation on the 5-point Wrinkle Scale (5WS)*

- Subject has signed institutional review board (IRB)-approved informed consent form

Exclusion Criteria:

- Subject takes any medication or dietary supplement regularly that affects blood
clotting (e.g., Coumadin, aspirin, clopidogrel) or increases the risk of
bleeding/bruising

- Subject has had prior surgery that alters the subcutaneous anatomy of the target
treatment sites

- The investigator is unable to substantially lessen facial lines by physical
separation

- Subject has undergone another facial cosmetic procedures at or above the level of the
cheekbones within the past 6 months

- Subject is participating in another facial cosmetic research study

Patient has any of following conditions:

- History of facial nerve palsy

- Marked facial asymmetry

- Ptosis

- Excessive dermatochalasis

- Deep dermal scarring

- Thick sebaceous skin

- History of neuromuscular disorder

- Chronic dry eye symptoms

- Allergy or intolerance to lidocaine

- Other local skin condition (eg, skin infection) at target treatment site

- Any physical or psychiatric condition that in the investigator's opinion would
prevent adequate study participation