The Effect of Insulin Degludec in Combination With Liraglutide and Metformin in Subjects With Type 2 Diabetes Qualifying for Treatment Intensification



Status:Completed
Conditions:Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - Any
Updated:9/27/2017
Start Date:October 1, 2012
End Date:December 31, 2013

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This trial is conducted in Africa, Asia, Europe and North America. The purpose of the trial
is to investigate the effect of insulin degludec (IDeg) in combination with liraglutide
(Lira) and metformin (at least 1500 mg daily or maximum tolerated dose) in subjects with type
2 diabetes qualifying for treatment intensification.


Inclusion Criteria:

- Type 2 diabetes

- Insulin naïve

- Ongoing treatment with metformin or metformin in combination with either sulphonylurea
(SU), glinides, dipeptidyl peptidase-IV (DPP-IV) inhibitors or exenatide (only twice
daily (BID))

- Glycosylated haemoglobin (HbA1c) (by central laboratory analysis): a. 7.5-10.0 % (both
inclusive) for subjects on metformin monotherapy, b. 7.0-9.0 % (both inclusive) for
subjects on metformin in combination with either SU, glinides, DPP-IV inhibitors or
exenatide (only BID)

Exclusion Criteria:

- Treatment with glucose-lowering agent(s) other than stated in the inclusion criteria
within 12 weeks

- Calcitonin equal to or above 50 pg/mL

- Stroke; heart failure New York Heart Association (NYHA) class III or IV; myocardial
infarction; unstable angina pectoris; or coronary arterial bypass graft or
angioplasty; all within 24 weeks

- Current or past (within the last 5 years) malignant neoplasms (except basal cell and
squamous cell carcinoma)
We found this trial at
63
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Spring Valley, California 91978
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Anaheim, California 92801
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Austin, Texas 78731
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Boynton Beach, Florida 33472
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Buckley, Michigan 49620
1857
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Chapel Hill, North Carolina 27599
2194
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Chattanooga, Tennessee 37404
1855
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Chesterfield, Missouri 63017
1552
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Chicago, Illinois 60612
1728
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Cincinnati, Ohio 45229
1881
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Clearwater, Florida 33756
2117
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Concord, California 94520
353
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Dallas, Texas 75231
1225
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1894
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Dayton, OH
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Decatur, Georgia 30033
1924
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Delta, British Columbia
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Escondido, California 92025
84
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Franklin, Ohio 45005
1891
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Fresno, California 93702
209
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Greensboro, North Carolina 27408
2151
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Greer, South Carolina 29651
2027
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Henderson, Nevada 89052
213
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Hollywood, Florida 33024
2318
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Houston, Texas 77030
1357
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Humboldt, Tennessee 38343
1646
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Huntington Beach, California 92648
28
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Hyattsville, Maryland 20782
2285
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Irving, Texas 75061
1213
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Jacksonville, Florida 32207
2131
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Kingsport, Tennessee 37660
1994
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La Jolla, California 92037
95
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Lawrenceville, New Jersey 08648
2396
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Los Angeles, California 90027
16
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Lubbock, Texas 79423
927
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Metairie, Louisiana 70002
1649
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Miami, Florida 33136
2321
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Milwaukee, Wisconsin 53209
1729
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Monterey, California 93940
279
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Morehead City, North Carolina 28557
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Nashua, New Hampshire 03063
2556
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Nashville, Tennessee 37203
1762
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New Port Richey, Florida 34652
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Newport News, Virginia 23606
2328
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Northport, New York 11768
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Paducah, Kentucky 42003
1659
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Palm Harbor, Florida 34684
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Perry, Georgia 31069
1974
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Philadelphia, Pennsylvania 19104
2373
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Roswell, Georgia 30076
1918
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Round Rock, Texas 78681
1208
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Saint George, Utah 84790
325
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Salt Lake City, Utah 84132
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San Antonio, Texas 78224
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Simpsonville, South Carolina 29681
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Smithtown, New York 11787
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Spokane, Washington 99202
939
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Springfield, Illinois 62702
1610
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Sugar Land, Texas 77479
1345
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Tampa, Florida 33612
2134
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Toms River, New Jersey 08755
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Topeka, Kansas 66606
1282
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Walnut Creek, California 94598
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West Seneca, New York 14224
2184
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