Safety, Tolerability, Pharmacokinetics of EVP-0962 and Effects of EVP-0962 on Cerebral Spinal Fluid Amyloid Concentrations in Healthy Subjects and in Subjects With Mild Cognitive Impairment or Early Alzheimer's Disease

This is a randomized, double-blind, sequential escalating repeat daily dose study conducted
in two parts. The first part is being conducted in healthy subjects and will evaluate
safety, tolerability, and pharmacokinetics and pharmacodynamics of escalating EVP-0962 doses
(10, 50 100 and 200 mg) or matching placebo following once-daily administration for 14 days.
The second part will evaluate the safety, tolerability and pharmacokinetics and
pharmacodynamics of EVP-0962 following once-daily administration for 14 days in patients
with mild cognitive impairment or early Alzheimer's disease at the dose level selected based
on the available safety, pharmacokinetics and pharmacodynamics observations in the first
part.

Inclusion Criteria:

- Part 1: Male and female subjects between the ages of 45 to 65 (inclusive) in good
health with a BMI of 18-32 kg/m2 and negative urine drug screen of abuse test.

- Part 2: Male and female subjects between the ages of 45 to 85 (inclusive), MRI/CT
scans compatible with diagnosis of MCI or early AD, meets the classification of MCI
due to AD as defined by the National Institute on Aging-Alzheimer's Association, and
a BMI of 18-32 kg/m2(inclusive). Subjects must meet the following Cognitive criteria:
Subject Memory Complaint, cognitive impairment in one or more areas, CDR-SB score
less than or equal 1.0, MMSE greater than 24, and no impairment in social or
occupational functioning.

Exclusion Criteria:

- History of seizure disorder, symptomatic orthostatic hypotension, QTc values greater
than 450 ms, positive drug screening tests

- Pregnancy, nursing, (or if fertile female) not willing to utilize birth control
measures during study

- C-SSRS suicidal ideation score of 4 or 5

- Unwilling to abstain from vigorous exercise

- Concurrent disease other than MCI or early AD that is attributing to patient's
cognitive impairment.

- Lumbar spine X-rays show anatomic contraindications to lumbar puncture

- History of spinal surgery or chronic low back pain

- History of migraine headaches