A Study in Participants With Moderate to Severe Psoriasis (UNCOVER-3)



Status:Active, not recruiting
Conditions:Psoriasis
Therapuetic Areas:Dermatology / Plastic Surgery
Healthy:No
Age Range:18 - Any
Updated:11/4/2018
Start Date:July 28, 2012
End Date:August 15, 2019

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A 12-Week Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Comparing the Efficacy and Safety of LY2439821 to Etanercept and Placebo in Patients With Moderate to Severe Plaque Psoriasis With a Long-Term Extension Period

This study will assess the safety and efficacy of ixekizumab (LY2439821), compared to
etanercept and placebo in participants with moderate to severe chronic plaque psoriasis.


Inclusion Criteria:

- Presents with chronic plaque psoriasis based on a confirmed diagnosis of chronic
psoriasis for at least 6 months prior to randomization

- At least 10% Body Surface Area (BSA) of Psoriasis at screening and at randomization

- sPGA score of at least 3 and PASI score of at least 12 at screening and at
randomization

- Candidate for phototherapy and/or systemic therapy

- Men must agree to use a reliable method of birth control or remain abstinent during
the study

- Women must agree to use reliable birth control or remain abstinent during the study
and for at least 12 weeks after stopping treatment

Exclusion Criteria:

- Pustular, erythrodermic, and/or guttate forms of psoriasis

- History of drug-induced psoriasis

- Prior use of etanercept

- Clinically significant flare of psoriasis during the 12 weeks prior to randomization

- Concurrent or recent use of any biologic agent

- Received non-biologic systemic psoriasis therapy or phototherapy (including psoralens
and ultraviolet A [PUVA], ultraviolet B [UVB]) within the previous 4 weeks; or had
topical psoriasis treatment within the previous 2 weeks prior to randomization

- Cannot avoid excessive sun exposure or use of tanning booths for at least 4 weeks
prior to randomization and during the study

- Have participated in any study with interleukin 17 (IL-17) antagonists, including
ixekizumab

- Serious disorder or illness other than plaque psoriasis

- Serious infection within the last 3 months

- Breastfeeding or nursing (lactating) women
We found this trial at
42
sites
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Omaha, NE
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Albuquerque, NM
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Anderson, SC
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Ann Arbor, MI
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Arlington Heights, Illinois 60004
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Arlington Heights, IL
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Aurora, CO
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Bell Gardens, CA
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Beverly Hills, California 90211
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Beverly Hills, CA
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Boston, MA
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Buenos Aires,
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Chicago, IL
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East Windsor, NJ
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Hazleton, PA
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High Point, NC
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Indianapolis, IN
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Jacksonville, FL
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Louisville, KY
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Miami, FL
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New Haven, CT
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Portland, OR
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West Des Moines, IA
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West Jordan, UT
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Winston-Salem, NC
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