Impact of Buspirone Maintenance on the Reinforcing Effects of Cocaine
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 4/21/2016 |
| Start Date: | September 2012 |
| End Date: | December 2014 |
Human Laboratory Study of the Impact of Buspirone Maintenance on the Reinforcing, Subjective and Performance Effects of Cocaine
Cocaine use disorders are an unrelenting public health concern. Intensive research efforts
have yielded behavioral interventions that reduce cocaine use, however, these interventions
are not universally effective and treatment effects diminish over time. Development of a
pharmacotherapy that enhances the efficacy of these interventions is a priority for the
National Institute on Drug Abuse. This study proposes to determine the impact of buspirone
maintenance on self-administration of cocaine and alternative reinforcers. These preliminary
data will be used to support further research developing buspirone as a pharmacotherapy for
cocaine use disorders. We hypothesize that buspirone will attenuate the reinforcing effects
of cocaine and increase the reinforcing effects of alternative reinforcers.
have yielded behavioral interventions that reduce cocaine use, however, these interventions
are not universally effective and treatment effects diminish over time. Development of a
pharmacotherapy that enhances the efficacy of these interventions is a priority for the
National Institute on Drug Abuse. This study proposes to determine the impact of buspirone
maintenance on self-administration of cocaine and alternative reinforcers. These preliminary
data will be used to support further research developing buspirone as a pharmacotherapy for
cocaine use disorders. We hypothesize that buspirone will attenuate the reinforcing effects
of cocaine and increase the reinforcing effects of alternative reinforcers.
Inclusion Criteria:
- Recent cocaine use
Exclusion Criteria:
- Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians
deem clinically significant
- Current or past histories of substance abuse or dependence that are deemed by the
study physicians to interfere with study completion
- History of serious physical disease, current physical disease, impaired
cardiovascular functioning, chronic obstructive pulmonary disease, history of seizure
or current or past histories of serious psychiatric disorder that in the opinion of
the study physician would interfere with study participation will be excluded from
participation
- Females not currently using effective birth control
- Contraindications to cocaine or buspirone
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