A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome



Status:Completed
Conditions:Peripheral Vascular Disease, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:45 - Any
Updated:8/3/2016
Start Date:April 2008
End Date:September 2012

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-blind, Placebo-controlled Study Assessing the Effect of RO4607381 on Cardiovascular Mortality and Morbidity in Clinically Stable Patients With a Recent Acute Coronary Syndrome

This study will evaluate the potential of RO4607381 to reduce cardiovascular morbidity and
mortality in stable coronary heart disease patients with recent Acute Coronary Syndrome
(ACS) and evaluate the long term safety profile of the drug. Eligible patients in stable
condition will be randomized to receive either RO4607381 600mg po or placebo po, daily,
together with a background of standard medication for ACS (including aspirin,
antihypertensives and statins). The anticipated time on study treatment is 2+ years, and the
target sample size is 15,600 individuals.


Inclusion Criteria:

- adult patients, >=45 years of age;

- recently hospitalized for ACS;

- clinically stable;

- receiving evidence-based medical and dietary management of dyslipidemia.

Exclusion Criteria:

- uncontrolled diabetes;

- clinically unstable;

- severe anemia;

- uncontrolled hypertension;

- concomitant treatment with any other drug raising HDL-C (eg niacin, fibrates).
We found this trial at
412
sites
Clinical Trial Facility in Monroe Washington
Monroe, Washington 98272
1400
mi
from
Monroe, WA
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Clinical Trial Facility in Abington Pennsylvania
Abington, Pennsylvania 19001
1227
mi
from
Abington, PA
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Clinical Trial Facility in Aiken South Carolina
Aiken, South Carolina
947
mi
from
Aiken, SC
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Clinical Trial Facility in Akron Ohio
Akron, Ohio
898
mi
from
Akron, OH
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Clinical Trial Facility in Albany New York
Albany, New York 12205
1306
mi
from
Albany, NY
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Clinical Trial Facility in Albuquerque New Mexico
Albuquerque, New Mexico
523
mi
from
Albuquerque, NM
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Clinical Trial Facility in Alexandria Louisiana
Alexandria, Louisiana 71301
540
mi
from
Alexandria, LA
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Clinical Trial Facility in Allentowm Pennsylvania
Allentowm, Pennsylvania 18105
1209
mi
from
Allentowm, PA
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Clinical Trial Facility in Almirante Brown
Almirante Brown,
5615
mi
from
Almirante Brown,
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Clinical Trial Facility in Alpena Michigan
Alpena, Michigan 49707
897
mi
from
Alpena, MI
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Clinical Trial Facility in Altanta Georgia
Altanta, Georgia
927
mi
from
Altanta, GA
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Clinical Trial Facility in Altoona Pennsylvania
Altoona, Pennsylvania 16602
1055
mi
from
Altoona, PA
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Clinical Trial Facility in Ames Iowa
Ames, Iowa 50010
370
mi
from
Ames, IA
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Clinical Trial Facility in Anaheim California
Anaheim, California 92801
1157
mi
from
Anaheim, CA
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Clinical Trial Facility in Anderson Indiana
Anderson, Indiana
671
mi
from
Anderson, IN
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Clinical Trial Facility in Ann Arbor Michigan
Ann Arbor, Michigan 48109
808
mi
from
Ann Arbor, MI
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Clinical Trial Facility in Asheville North Carolina
Asheville, North Carolina
858
mi
from
Asheville, NC
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Clinical Trial Facility in Athens Ohio
Athens, Ohio 45701
855
mi
from
Athens, OH
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Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
801
mi
from
Atlanta, GA
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Clinical Trial Facility in Aurora Illinois
Aurora, Illinois 60506
573
mi
from
Aurora, IL
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Clinical Trial Facility in Austin Texas
Austin, Texas 78744
522
mi
from
Austin, TX
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Clinical Trial Facility in Aventura Florida
Aventura, Florida 33108
1314
mi
from
Aventura, FL
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Clinical Trial Facility in Bakersfield California
Bakersfield, California 93301
1184
mi
from
Bakersfield, CA
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Clinical Trial Facility in Baltimore Maryland
Baltimore, Maryland
1148
mi
from
Baltimore, MD
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Clinical Trial Facility in Bangor Maine
Bangor, Maine 04402
1575
mi
from
Bangor, ME
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Clinical Trial Facility in Bannockburn Illinois
Bannockburn, Illinois
609
mi
from
Bannockburn, IL
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Clinical Trial Facility in Bartlesville Oklahoma
Bartlesville, Oklahoma 74006
125
mi
from
Bartlesville, OK
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Clinical Trial Facility in Beaver Pennsylvania
Beaver, Pennsylvania 15009
957
mi
from
Beaver, PA
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Clinical Trial Facility in Bel Air Maryland
Bel Air, Maryland 21014
1162
mi
from
Bel Air, MD
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Clinical Trial Facility in Bellevue Washington
Bellevue, Washington 98007
1402
mi
from
Bellevue, WA
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Clinical Trial Facility in Bellflower California
Bellflower, California 90706
1165
mi
from
Bellflower, CA
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Clinical Trial Facility in Beloit Wisconsin
Beloit, Wisconsin
568
mi
from
Beloit, WI
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Clinical Trial Facility in Bend Oregon
Bend, Oregon
1296
mi
from
Bend, OR
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Clinical Trial Facility in Beverly Hills California
Beverly Hills, California 90211
1175
mi
from
Beverly Hills, CA
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Clinical Trial Facility in Biddeford Maine
Biddeford, Maine
1481
mi
from
Biddeford, ME
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Clinical Trial Facility in Billerica Massachusetts
Billerica, Massachusetts 01821
1434
mi
from
Billerica, MA
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Clinical Trial Facility in Billings Montana
Billings, Montana 59101
780
mi
from
Billings, MT
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Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
683
mi
from
Birmingham, AL
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Clinical Trial Facility in Bloomfield Michigan
Bloomfield, Michigan
837
mi
from
Bloomfield, MI
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Clinical Trial Facility in Boise Idaho
Boise, Idaho 83712
1039
mi
from
Boise, ID
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Clinical Trial Facility in Boston Massachusetts
Boston, Massachusetts
1444
mi
from
Boston, MA
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Clinical Trial Facility in Boynton Beach Florida
Boynton Beach, Florida 33472
1292
mi
from
Boynton Beach, FL
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Clinical Trial Facility in Bridgeport Connecticut
Bridgeport, Connecticut
1330
mi
from
Bridgeport, CT
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Clinical Trial Facility in Bridgewater New Jersey
Bridgewater, New Jersey 08807
1254
mi
from
Bridgewater, NJ
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Clinical Trial Facility in Bristol Tennessee
Bristol, Tennessee 37620
864
mi
from
Bristol, TN
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Clinical Trial Facility in Bronx New York
Bronx, New York
1291
mi
from
Bronx, NY
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Clinical Trial Facility in Brooklyn New York
Brooklyn, New York 11215
1287
mi
from
Brooklyn, NY
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Clinical Trial Facility in Bryn Mawr Pennsylvania
Bryn Mawr, Pennsylvania
966
mi
from
Bryn Mawr, PA
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Clinical Trial Facility in Buena Park California
Buena Park, California 90620
1160
mi
from
Buena Park, CA
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Clinical Trial Facility in Buffalo New York
Buffalo, New York
1056
mi
from
Buffalo, NY
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Clinical Trial Facility in Burbank California
Burbank, California 91505
1171
mi
from
Burbank, CA
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Clinical Trial Facility in Burke Virginia
Burke, Virginia 22015
1114
mi
from
Burke, VA
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Clinical Trial Facility in Burlington Wisconsin
Burlington, Wisconsin 53105
606
mi
from
Burlington, WI
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Clinical Trial Facility in Cadillac Michigan
Cadillac, Michigan 49601
786
mi
from
Cadillac, MI
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Clinical Trial Facility in Camp Hill Pennsylvania
Camp Hill, Pennsylvania 17011
1132
mi
from
Camp Hill, PA
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Clinical Trial Facility in Canton Ohio
Canton, Ohio 44718
900
mi
from
Canton, OH
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Clinical Trial Facility in Carmichael California
Carmichael, California 95608
1274
mi
from
Carmichael, CA
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Clinical Trial Facility in Cary North Carolina
Cary, North Carolina 27518
1060
mi
from
Cary, NC
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Clinical Trial Facility in Centerville Ohio
Centerville, Ohio 45459
747
mi
from
Centerville, OH
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Clinical Trial Facility in Chapel Hill North Carolina
Chapel Hill, North Carolina
1043
mi
from
Chapel Hill, NC
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Clinical Trial Facility in Charleston South Carolina
Charleston, South Carolina 29412
1064
mi
from
Charleston, SC
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Clinical Trial Facility in Charlotte North Carolina
Charlotte, North Carolina 28207
959
mi
from
Charlotte, NC
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Clinical Trial Facility in Charlottesville Virginia
Charlottesville, Virginia
1053
mi
from
Charlottesville, VA
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Clinical Trial Facility in Chaska Minnesota
Chaska, Minnesota 55318
533
mi
from
Chaska, MN
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Clinical Trial Facility in Chicago Illinois
Chicago, Illinois
610
mi
from
Chicago, IL
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Clinical Trial Facility in Chipley Florida
Chipley, Florida
849
mi
from
Chipley, FL
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Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
726
mi
from
Cincinnati, OH
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Clinical Trial Facility in Clarksburg West Virginia
Clarksburg, West Virginia 26301
949
mi
from
Clarksburg, WV
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Clinical Trial Facility in Clearwater Florida
Clearwater, Florida 33756
1102
mi
from
Clearwater, FL
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Clinical Trial Facility in Cleveland Ohio
Cleveland, Ohio
895
mi
from
Cleveland, OH
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Clinical Trial Facility in Clifton New Jersey
Clifton, New Jersey
1279
mi
from
Clifton, NJ
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Clinical Trial Facility in Colonial Heights Virginia
Colonial Heights, Virginia 23834
866
mi
from
Colonial Heights, VA
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Clinical Trial Facility in Colorado Springs Colorado
Colorado Springs, Colorado 80910
383
mi
from
Colorado Springs, CO
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Clinical Trial Facility in Columbia Maryland
Columbia, Maryland 21044
1134
mi
from
Columbia, MD
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Clinical Trial Facility in Columbia Missouri
Columbia, Missouri 65201
310
mi
from
Columbia, MO
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Clinical Trial Facility in Columbia South Carolina
Columbia, South Carolina
972
mi
from
Columbia, SC
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Clinical Trial Facility in Columbus Georgia
Columbus, Georgia 31904
811
mi
from
Columbus, GA
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Clinical Trial Facility in Columbus Ohio
Columbus, Ohio 43214
810
mi
from
Columbus, OH
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Clinical Trial Facility in Concord North Carolina
Concord, North Carolina 28025
969
mi
from
Concord, NC
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Clinical Trial Facility in Corona California
Corona, California 92879
1136
mi
from
Corona, CA
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Clinical Trial Facility in Costa Mesa California
Costa Mesa, California 92626
1158
mi
from
Costa Mesa, CA
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Clinical Trial Facility in Council Bluffs Iowa
Council Bluffs, Iowa 51501
263
mi
from
Council Bluffs, IA
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Clinical Trial Facility in Covington Georgia
Covington, Georgia 30015
833
mi
from
Covington, GA
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Clinical Trial Facility in Crystal River Florida
Crystal River, Florida 34429
1069
mi
from
Crystal River, FL
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Clinical Trial Facility in Dallas Texas
Dallas, Texas 75390
349
mi
from
Dallas, TX
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Clinical Trial Facility in Danbury Connecticut
Danbury, Connecticut 06810
1317
mi
from
Danbury, CT
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Clinical Trial Facility in Danville Virginia
Danville, Virginia 24541
1013
mi
from
Danville, VA
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Clinical Trial Facility in Davenport Iowa
Davenport, Iowa 52803
466
mi
from
Davenport, IA
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Clinical Trial Facility in Daytona Beach Florida
Daytona Beach, Florida 32117
1128
mi
from
Daytona Beach, FL
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Clinical Trial Facility in Dearborn Michigan
Dearborn, Michigan 48124
831
mi
from
Dearborn, MI
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Clinical Trial Facility in Decatur Georgia
Decatur, Georgia 30033
805
mi
from
Decatur, GA
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Clinical Trial Facility in Deerfield Beach Florida
Deerfield Beach, Florida 33442
1300
mi
from
Deerfield Beach, FL
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Clinical Trial Facility in Delray Florida
Delray, Florida 33445
1293
mi
from
Delray, FL
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Clinical Trial Facility in Delray Beach Florida
Delray Beach, Florida 33406
1285
mi
from
Delray Beach, FL
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Clinical Trial Facility in Denver Colorado
Denver, Colorado
409
mi
from
Denver, CO
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Clinical Trial Facility in Detroit Michigan
Detroit, Michigan
841
mi
from
Detroit, MI
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Clinical Trial Facility in Downington Pennsylvania
Downington, Pennsylvania 19335
1196
mi
from
Downington, PA
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Clinical Trial Facility in Doylestown Pennsylvania
Doylestown, Pennsylvania 18901
1227
mi
from
Doylestown, PA
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Clinical Trial Facility in Duluth Minnesota
Duluth, Minnesota
689
mi
from
Duluth, MN
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Clinical Trial Facility in Durham North Carolina
Durham, North Carolina
1051
mi
from
Durham, NC
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Clinical Trial Facility in E. Bridgewater Massachusetts
E. Bridgewater, Massachusetts 02333
1448
mi
from
E. Bridgewater, MA
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