Smart-phone Application to Promote Medication Adherence in Adolescents and Young Adults (AYA) With Cancer

Non-adherence to oral medications is a prevalent problem in adolescents and young adults
(AYA) with cancer that may impact both survival and quality of life while on treatment. The
purpose of this study is to explore use of a smart-phone medication reminder application to
promote adherence to oral medications by AYA with cancer. The study's primary aim is to
explore the feasibility and acceptability of using a smart-phone medication reminder
application to promote adherence to oral medications by AYA with cancer as well as to
characterize application use. Secondary aims include: 1) to obtain initial estimates of
intervention effect- measured by pre-intervention to post-intervention differences in
perceived behavioral control for adherence, intention to adhere, and adherence behavior - to
inform design of a future trial powered to detect a clinically significant effect of
smart-phone medication reminder application use on adherence to oral medications; and 2) to
examine the relationships among perceived behavioral control for adherence, intention to
adhere, and adherence behavior. A pre-post single group design will be used. Data will be
collected weekly for 4 weeks before introduction of the intervention and for 8 weeks
following introduction of the intervention. Analytic approaches will include descriptive
statistics and generalized estimating equation (GEE) modeling.

Inclusion criteria:

1)15-29 year olds receiving treatment for any type of cancer, either primary or
recurrent/relapsed disease.

2) Patient has completed at least one month of therapy

3)Patient is expected to remain on therapy for 3 month duration of study

4) Patient has an iPhone, iPad, or iTouch running iOS 4.0 or later

5) Patient is willing to use a smart-phone medication reminder application-

Exclusion Criteria:

1)Patients who are unable to speak/read/write English as required for use of smart-phone
medication reminder application and completion of study measures.