ONO-2952 Single-dose PET Study in Healthy Adult Subjects

Conditions:Healthy Studies
Therapuetic Areas:Other
Age Range:18 - 55
Start Date:August 2012
Contact:Brenda Souza

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Open-Label, Single-Center, Single Dose Positron Emission Topography (PET) Using [11C]PBR28 to Evaluate Brain Translocator Protein 18KDa (TSPO) Occupancy of ONO-2952 in Healthy Adult Subjects

The primary objective of this study is to evaluate the brain TSPO occupancy of ONO-2952 in
healthy adult subjects after a single dose using [11C]PBR28 as a specific PET ligand for
TSPO. The secondary objective is to evaluate the relationship between TSPO occupancy and
the plasma concentration of ONO-2952 and to investigate the safety and tolerability of
ONO-2952 in healthy subjects.

Inclusion Criteria:

- Healthy non-smoking male or female subjects (18-55 inclusive)

- Body mass index (BMI) of 19-35 kg/m2 (inclusive)

- For females, surgically sterilized, postmenopausal, or who are non- lactating and
agree to use a double barrier method of contraception

Exclusion Criteria:

- History or presence of clinically significant disease
We found this trial at
Pittsburgh, Pennsylvania 15218
Pittsburgh, PA
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