Autonomic Phenotype Before and After Akt Inhibition



Status:Recruiting
Conditions:Skin Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 80
Updated:2/7/2015
Start Date:May 2012
End Date:May 2016
Contact:Satish Raj, MD, MSCI
Email:adcresearch@vanderbilt.edu
Phone:615-322-2931

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Autonomic Phenotype Before and After Akt Inhibition: Akt Therapy for Melanoma Sub-study

Some Akt inhibitors have produced functional cardiovascular effects such as marked
hypotension that may limit their clinical benefit. There are no current data on whether
this autonomic failure presents in humans at clinically used doses. We will test the
hypothesis that Akt inhibition causes an acute decrease in sympathetic tone and lowers blood
pressure.


Inclusion Criteria:

- Diagnosed with melanoma with a BRAF mutation and relapse following therapy with a
BRAF inhibitor

- Enrolled in a clinical trial through the Vanderbilt Ingram Cancer Center (VICC)
including an arm with an oral Akt inhibitor

- Able and willing to provide informed consent

Exclusion Criteria:

- Factors which in the investigator's opinion would prevent the participant from
completing the protocol, including poor compliance during previous studies or an
unpredictable schedule

- Unable to give informed consent
We found this trial at
1
site
2201 West End Ave
Nashville, Tennessee 37232
(615) 322-7311
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