Inflammation and the Heart
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Arthritis, Rheumatoid Arthritis |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/6/2017 |
| Start Date: | August 2012 |
| End Date: | December 2018 |
Studies have shown that people with rheumatoid arthritis (RA) have a higher rate of heart
disease than people that do not have RA. we believe this is caused by the inflammation
produced by RA.
disease than people that do not have RA. we believe this is caused by the inflammation
produced by RA.
Aim 1: We want to study people with RA to see if we can detect very early changes in their
heart muscle and compare these results to people who do not have RA.
Aim 2: We want to study people with RA, who have at least 4 swollen joints, before and 6
months after starting a disease modifying therapy to see if there are any changes in the
heart muscle on treatment.
heart muscle and compare these results to people who do not have RA.
Aim 2: We want to study people with RA, who have at least 4 swollen joints, before and 6
months after starting a disease modifying therapy to see if there are any changes in the
heart muscle on treatment.
Inclusion Criteria:
- Written informed consent
- Age >= 18
- RA only: meet American College of Rheumatology(ACR)criteria for Diagnosis of RA
- Controls only: no evidence of RA or other inflammatory disease
Exclusion Criteria:
- Previous or current heart failure or ischemic cardiovascular disease (eg stroke,
myocardial infarction, angina, CABG, stent).
- Atrial fibrillation.
- Known structural or functional cardiac abnormality, including pulmonary htn.
- Glomerular filtration rate < 60 ml/min.
- Pregnancy or breastfeeding.
- Unable to perform MRI (claustrophobia, unable to fit in magnet,pacemaker,defibrillator
or non-MR safe implant).
- Hypersensitivity to gadolinium.
We found this trial at
1
site
Click here to add this to my saved trials
