The Role of Substance P on Perception of Breathlessness During Resistive Load Breathing
| Status: | Recruiting |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 50 - Any |
| Updated: | 3/30/2013 |
| Start Date: | April 2012 |
| Contact: | Donald A Mahler, MD |
| Email: | Donald.a.mahler@hitchcock.org |
| Phone: | 603 650-5533 |
Substance P is released from sensory nerves and transmits pain information into the central
nervous system. As pain and dyspnea share many characteristics, including similar
neurological pathways, it is possible that substance P may contribute to the sensation of
dyspnea. The hypothesis of the study is that patients with chronic obstructive pulmonary
disease (COPD) will provide lower ratings of breathlessness during resistive load breathing
with oral aprepitant, a medication that blocks the activity of substance P, compared with
placebo.
Inclusion Criteria:
- 50 years of age or older
- diagnosis of COPD
- former smoker > 10 pack-years
- clinical diagnosis of chronic bronchitis
- post-bronchodilator forced expiratory volume in one second (FEV1) 30 - 80% predicted
- FEV1/forced vital capacity ratio less than or equal to 70%
Exclusion Criteria:
- current smoker
- pregnant women
- concomitant disease that might interfere with study procedures
- peripheral vascular disease or cold hypersensitivity
- drugs that might interfere with aprepitant
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