Enhancing Exposure Therapy for Post-traumatic Stress Disorder



Status:Recruiting
Conditions:Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 65
Updated:4/2/2016
Start Date:April 2012
End Date:March 2018
Contact:Michael J Telch, Ph.D.
Email:Telch@austin.utexas.edu
Phone:(512) 404-9118

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Enhancing Exposure Therapy for PTSD: An Investigation of Non-Pharmacological Augmentation Strategies

This study is investigating a new brief psychotherapy for post-traumatic stress disorder
(PTSD) which, modifies an already proven psychotherapy for PTSD by adding two new components
and modifying several others. The goal of the study is to determine whether this
experimental treatment outperforms the well-established standard treatment.

This study is investigating a new brief psychotherapy for post-traumatic stress disorder
(PTSD) which, modifies an already proven psychotherapy for PTSD by adding two new components
and modifying several others. The goal of the study is to determine whether this
experimental treatment outperforms the well-established standard treatment. Individuals
between the ages of 18-65 with chronic PTSD are randomly assigned to one of three
psychotherapy conditions: (a) brief enhanced exposure therapy; (b) standard prolonged
exposure therapy; and (c) delayed standard exposure therapy. All study participants undergo
a phone and face-to-face screening assessment to determine study eligibility and baseline
(pretreatment-Week 0) symptom severity. Upon completing treatment, participants undergo
three additional assessment visits (Week 6, Week 10, and Week 22). During each of these
outcome assessment visits, participants complete a structured clinical interview and a
battery of computer-administered questionnaires.

Inclusion Criteria:

1. Current primary PTSD diagnosis based on DSM-IV criteria, with a minimum duration of
12 weeks since the traumatic event.

2. Between the age of 18 and 65.

3. Medication status stable for at least 6 weeks

Exclusion Criteria:

1. Current diagnosis of schizophrenia, delusional disorder, or organic mental disorder
as defined by the DSM-IV.

2. Current diagnosis of bipolar disorder, depression with psychotic features, or
depression severe enough to require immediate psychiatric treatment (i.e., serious
suicide risk with intent and plan).

3. Current diagnosis of alcohol or substance dependence within the 3 previous months.

4. Unwilling or unable to discontinue current trauma-focused psychotherapy.

5. Ongoing intimate relationship with the perpetrator (in assault-related PTSD cases).

6. Other severe acute or chronic medical or psychiatric condition that, in the judgment
of the Medical Director, would make the participant inappropriate for entry.
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