A Pilot Study: Metformin Therapy in Heart Failure Patients With Early Diabetes or at High Risk of Developing Diabetes (Pre-Diabetes)
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Endocrine, Diabetes |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 5/27/2013 |
| Start Date: | December 2011 |
| End Date: | December 2012 |
The Ahmanson-UCLA Cardiomyopathy Center is conducting a clinical research study that will
assess the use of the medication metformin to improve quality of life, exercise capacity,
and improved outcomes in heart failure patients with pre-DM or early DM (type II).
If the patient participates in this study, the patient will receive the drug metformin for
approximately 3 months. During the study the patient will undergo comprehensive testing
which includes blood draws and echocardiograms. The patient will also fill out a
questionnaire. The patient must be 18 years old to participate.
Inclusion Criteria:
- symptomatic HF of any etiology
- age ≥ 18 years
- fasting blood sugar equal or greater than 100 mg/dL, or pre-DM (HbA1c 5.7 - 6.4%) or
early DM (HbA1c ≥ 6.5%)
Exclusion Criteria:
- current metformin therapy or other anti-diabetic therapy
- previous intolerance to metformin therapy
- renal dysfunction (Cr >1.5 in men or > 1.4 in women or creatinine clearance < 60
ml/minute)
- history of lactic acidosis
- current or planned pregnancy or breast-feeding
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