Depression Agency-Based Collaboration
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Anxiety, Depression, Major Depression Disorder (MDD) |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 60 - Any |
| Updated: | 4/21/2016 |
| Start Date: | March 2012 |
| End Date: | June 2016 |
Depression Agency-Based Collaborative (Depression ABC)
Seniors who receive supportive services face a variety of psychosocial vulnerabilities that
put them at risk for depression. One group with very high risk is older adults receiving
aging services through Medicaid waiver programs. This 3-year research uses a randomized
controlled clinical trial to assess the effectiveness of brief behavioral therapies (problem
solving therapy [PST] and Brief Behavioral Therapy for Insomnia [BBTI]) to prevent
depression in seniors receiving aging services.
put them at risk for depression. One group with very high risk is older adults receiving
aging services through Medicaid waiver programs. This 3-year research uses a randomized
controlled clinical trial to assess the effectiveness of brief behavioral therapies (problem
solving therapy [PST] and Brief Behavioral Therapy for Insomnia [BBTI]) to prevent
depression in seniors receiving aging services.
The research will determine (i) if a course of problem solving therapy (PST) and Brief
Behavioral Therapy for Insomnia (BBTI), with boosters, reduces incidence of major depressive
episodes over 12 months relative to usual care, and (ii) the extent to which behavioral
therapies achieve these effects through enhancement of protective factors, such as greater
self-efficacy, better targeting of services to address needs, and greater control over home
environments.
Periodic blood draws will be used to assess biosignatures of depression. Guiding our
investigations of pharmacogenetics, inflammation, and proteomics are synergistic
interactions among the serotonergic system, the HPA axis, systemic inflammation, growth
factors such as brain derived neuro-trophic factor (BDNF), psychosocial stressors, and
vascular co-morbidity. Genetic variation in vasopressin receptors, potentially involved in
both cardiovascular risk and social attachment, is also associated with recurrence of
depression. Similarly, genetic variation in inflammation may influence antidepressant
response and medical co-morbidity.
Behavioral Therapy for Insomnia (BBTI), with boosters, reduces incidence of major depressive
episodes over 12 months relative to usual care, and (ii) the extent to which behavioral
therapies achieve these effects through enhancement of protective factors, such as greater
self-efficacy, better targeting of services to address needs, and greater control over home
environments.
Periodic blood draws will be used to assess biosignatures of depression. Guiding our
investigations of pharmacogenetics, inflammation, and proteomics are synergistic
interactions among the serotonergic system, the HPA axis, systemic inflammation, growth
factors such as brain derived neuro-trophic factor (BDNF), psychosocial stressors, and
vascular co-morbidity. Genetic variation in vasopressin receptors, potentially involved in
both cardiovascular risk and social attachment, is also associated with recurrence of
depression. Similarly, genetic variation in inflammation may influence antidepressant
response and medical co-morbidity.
Inclusion Criteria:
- Age => 60 years
- Modified Mini Mental State (3MS) Examination =>80
- Receiving aging services or difficulty with 1+ ADL/IADL
- PHQ-9 score > 0 and <= 9 (and question 1 or 2 is >0)
Exclusion Criteria:
- Major depressive episode or anxiety disorder within 12 mo
- Ever diagnosed with bipolar disorder or schizophrenia
- Drug or alcohol use disorder within the past 12 months
- Currently taking antidepressants
- Currently taking antianxiety med >4x/week for past 4 weeks
We found this trial at
1
site
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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