Proton Radiotherapy for Stage I, IIA, and IIB Seminoma

This is a Phase II study using proton radiation therapy in addition to their standard care
in subjects who have Stage I, IIA, IIB Seminoma. Testicular cancer are the most common solid
cancers among men aged 20 to 35. Each subject must be 18 years of age or older and have a
histologically proven diagnosis of testicular cancer. In addition to a subject's routine
exams and tests, they will be asked to complete a series of quality of life questionnaires
before, during and after their treatment. All side effects/toxicities will be monitored and
recorded. Patients will be followed for a minimum of 5 years.

Inclusion Criteria

- Histological diagnosis; Histologically proven diagnosis of testicular seminoma; -
Histologically confirmed seminomatous germ cell tumor of the testis categorized as
either "classical" or "anaplastic;

- Stage I disease; Any pT N0 M0 S0-3 (Appendix B) [AJCC, 7th Ed.] (72); Stage IIA or
IIB disease;

- Any pT N1 M0 S0-3 (Appendix B) [AJCC, 7th Ed.] (72); Any pT N2 M0 S0-3 (Appendix B)
[AJCC, 7th Ed.] (72); (at the discretion of the principal investigators, bulky stage
IIB may be excluded from the study, according to National Comprehensive Cancer Center
Guidelines. 2. Laboratory evaluations; Semen analysis (patients will not be excluded
if they do not wish to have an analysis or their insurance denies the claim)
Follice-stimulating hormone (prior to the start of radiation) Luteinizing Hormone
(Prior to the start of radiation) Lactate Dehydrogenase (Prior to the start of
radiation) Human Chorionic Gonadotropic (Prior to the start of radiation) Complete
blood count (Prior to the start of radiation) Testosterone (prior to the start of
radiation) 3. Appropriate stage for protocol entry, as per protocol section 3.2.1, ,
based upon the following minimum diagnostic workup: History and physical examination,
including a complete list of current medications; Chest x-ray (PA and lateral views)
or CT Chest (within 3 months of study registration); Abdominal/pelvic CT scan or
Abd/pelvic MRI(within 3 months of study registration); Brain MRI if clinically
indicated; Bone scan if clinically indicated; 4. For stage I seminoma patients only,
definitive surgical intervention within ten weeks prior to registration; Patients
undergoing scrotal violations (scrotal orchiectomy, transscrotal biopsy, testicular
fine needle aspiration, scrotal exploration) will be eligible; 5. The patient is a
candidate for definitive external beam radiotherapy; The patient has had no prior
radiotherapy to the region of study; The patient has no inflammatory bowel disease,
active collagen vascular or connective tissue disorders, and no other medical or
social contraindications to radiotherapy, as determined by a participating radiation
oncologist; 6. Patient age: ³18 years; 7. Patient ECOG performance status: 0-1
(Appendix C); 8. For Stage II disease recurrence, rebiopsy is not clinically
indicated. Imaging suffices for confirmation of recurrence

Exclusion Criteria

- Prior radiotherapy to the region of the study cancer

- Prior radiation therapy for a different cancer or disease process is allowed,
provided there will be no overlap of radiation therapy fields between the
participant's prior and current course of radiation therapy, radiotherapy was
completed more than four weeks from first fraction of proton therapy administered in
this study, and the participant has recovered to Grade ≤1 toxicity related to prior
radiotherapy

- Chemotherapy administered for the diagnosis of seminoma

- Prior chemotherapy for a different cancer is allowed, provided therapy was completed
more than twelve months from first fraction of proton therapy administered in this
study and the participant has recovered to Grade ≤1 toxicity related to agents
previously administered

- Incomplete definitive surgical orchiectomy, including diagnostic biopsy alone

- Pelvic lymph node dissection for the diagnosis of seminoma

- An investigational drug administered for the diagnosis of seminoma given concurrently
or within four weeks of the first fraction of proton therapy administration

- Prior or concurrent second invasive malignancy other than non-melanoma skin cancer,
unless disease free for a minimum of five years

- Known severe, active co-morbidity, defined as follows:Any clinically significant
unrelated systemic illness, medical condition, or other factor, which at the
discretion of the Principal Investigators, would interfere in the safe and timely
completion of study procedures, compromise the patient's ability to tolerate the
protocol therapy, or is likely to interfere with the study procedures or results

- Cognitively impaired patients who cannot provide informed consent